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BGC0001038Hybrid

Pyralomicin 1a

Producing organism
Nonomuraea spiralis
Taxonomy
BacteriaActinomycetotaActinomycetesStreptosporangialesStreptosporangiaceaeNonomuraea
Biosynthetic class
NRPS (Type I);PKS (Type I)
Total steps
18
DOI
MIBiG entry
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pyralomicin 1a
C20H19Cl2NO7455.05 Da

Gene Cluster Map27 genes · 41,430 bp

MTAKSATKSAT10 kb41.4 kb visible · 41,430 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier (ACP)
AAdenylation (A)
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1
Start
+L-Proline
Step 11
Start
+Glucose
Step 2
prlK
Step 12
?
Step 3
prlK;prlS
Step 13
?
Step 4
prlJ
Step 14
?
Step 5
prlT
Step 15
?
Step 6
prlP
+Malonyl-CoA
Step 16
?
Step 7
prlQ
+Methylmalonyl-CoA
Step 17
?
Step 8
prlQ
+Malonyl-CoA
Step 9TE
prlR
Step 10
prlM, prlN, prlO
Step 18
prlH
Starting stepIntermediateFinal productModuleLoadingTENo modulePKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11038-1Start
L-Proline
O=C(O)[C@@H]1CCCN1
21038-2prlK
1038-1
from: 1038-1
O=C([R])[C@@H]1CCCN1
31038-3prlK;prlS
1038-2
from: 1038-2
O=C(O)[C@@H]1CCCN1
41038-4prlJ
1038-3
from: 1038-3
O=C(O)C1=CC=CN1
51038-5prlT
1038-4
from: 1038-4
O=C(O)C1=CC=C(Cl)N1
61038-6prlP
1038-5;Malonyl-CoA
from: 1038-5
O=C(CC(O)=O)C1=CC=C(Cl)N1
71038-7prlQ
1038-6;Methylmalonyl-CoA
from: 1038-6
O=C(CC(O)C(C(O)=O)C)C1=CC=C(Cl)N1
81038-8prlQ
1038-7;Malonyl-CoA
from: 1038-7
O=C(CC(O)C(/C=C/C(O)=O)C)C1=CC=C(Cl)N1
91038-9prlRTE
1038-8
from: 1038-8
O=C(C1=C(O)C=CC(C)=C1O)C2=CC=C(Cl)N2
101038-10prlM, prlN, prlO
1038-9
from: 1038-9
ClC1=C(O)C2=C(C(C)=C1)OC3=C(C=C(Cl)N3)C2=O
111038-11Start
Glucose
O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1O
121038-12?
1038-11
from: 1038-11
O=C([C@]([H])([C@](O)([C@](O)([C@](O)(COP(O)(O)=O)[H])[H])[H])O)CO
131038-13?
1038-12
from: 1038-12
O[C@@]([C@@H](O)[C@H](O)[C@@H]1O)(CO)CC1=O
141038-14?
1038-13
from: 1038-13
O[C@@]([C@@H](O)[C@H](O)[C@H]1O)(CO)CC1=O
151038-15?
1038-14
from: 1038-14
O[C@H]1[C@H](O)[C@@H](O)C(C=C1CO)=O
161038-16?
1038-15
from: 1038-15
O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)C=C1CO
171038-17?
1038-16
from: 1038-16
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])C=C1CO
181038prlH
1038-10;1038-17
from: 1038-10, 1038-17
ClC1=C(O)C2=C(C(C)=C1)OC3=C(C=C(Cl)N3[C@H]4[C@H](O)[C@@H](O)[C@H](O)C(CO)=C4)C2=O
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