NPdia
← Back to Repository
BGC0001036Hybrid

Polyoxypeptin

Producing organism
Streptomyces sp. MK498-98F14
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
13
DOI
MIBiG entry
View on MIBiG ↗
Loading…
polyoxypeptin
C45H76N8O15968.54 Da

Gene Cluster Map37 genes · 73,445 bp

AAAAAAAmTKSKSKSKSA10 kb73.4 kb visible · 73,445 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
EEpimerization (E)
DnDocking N-term
DcDocking C-term
MTMethyltransferase
AmTAminotransferase I/II
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

13 steps · 12 edges
Step 1
AGZ15472.1
+Methylmalonyl-CoA
Step 2
AGZ15473.1
+3-Methylpentanoyl…
Inactive: DH
Step 3
AGZ15474.1
+Malonyl-CoA
Step 4
AGZ15475.1
+Methylmalonyl-CoA
Step 5
AGZ15476.1, AGZ15455.1,…
+Leucine
Step 6
AGZ15458.1
+L-Piperazic acid
Step 7
AGZ15458.1, AGZ15455.1,…
+Alanine
Step 8
AGZ15459.1
+L-Piperazic acid
Step 9
AGZ15459.1, (AGZ15467.1…
+Proline
Step 10
AGZ15460.1, AGZ15455.1,…
+Valine
Step 11TE
AGZ15460.1
Step 12
AGZ15467.1/?
Step 13
AGZ15465.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11036-1AGZ15472.1—
Methylmalonyl-CoA
O=C(CC)O—
21036-2AGZ15473.1—
1036-1;3-Methylpentanoyl-CoA
from: 1036-1
O[C@H](CC)[C@@H](C[C@@H](C)CC)C(O)=O{'Inactive': ['DH']}
31036-3AGZ15474.1—
1036-2;Malonyl-CoA
from: 1036-2
O[C@H](CC)[C@@H](C[C@@H](C)CC)CCC(O)=O—
41036-4AGZ15475.1—
1036-3;Methylmalonyl-CoA
from: 1036-3
O[C@H](CC)[C@@H](C[C@@H](C)CC)CCC(C(C)C(O)=O)=O—
51036-5AGZ15476.1, AGZ15455.1, (AGZ15456.1/AGZ15469.1), (AGZ15461.1/AGZ15471.1)—
1036-4;Leucine
from: 1036-4
O=C(O)[C@@H](NC(C(C(CC[C@@H]1C[C@@H](C)CC)(O)O[C@@H]1CC)C)=O)[C@H](C(C)C)O—
61036-6AGZ15458.1—
1036-5;L-Piperazic acid
from: 1036-5
O=C(N1[C@H](C(O)=O)CCCN1)[C@@H](NC(C(C(CC[C@@H]2C[C@@H](C)CC)(O)O[C@@H]2CC)C)=O)[C@H](C(C)C)O—
71036-7AGZ15458.1, AGZ15455.1, (AGZ15456.1/AGZ15469.1), (AGZ15461.1/AGZ15471.1)—
1036-6;Alanine
from: 1036-6
O=C(N1[C@@H](C(N(O)C(C)C(O)=O)=O)CCCN1)[C@@H](NC(C(C(CC[C@@H]2C[C@@H](C)CC)(O)O[C@@H]2CC)C)=O)[C@H](C(C)C)O—
81036-8AGZ15459.1—
1036-7;L-Piperazic acid
from: 1036-7
O=C(N1[C@@H](C(N(O)C(C)C(N2[C@H](C(O)=O)CCCN2)=O)=O)CCCN1)[C@@H](NC(C(C(CC[C@@H]3C[C@@H](C)CC)(O)O[C@@H]3CC)C)=O)[C@H](C(C)C)O—
91036-9AGZ15459.1, (AGZ15467.1/?), AGZ15468.1—
1036-8;Proline
from: 1036-8
O=C(N1[C@@H](C(N(O)C(C)C(N2[C@@H](C(N3[C@H](C(O)=O)[C@@](O)(C)CC3)=O)CCCN2)=O)=O)CCCN1)[C@@H](NC(C(C(CC[C@@H]4C[C@@H](C)CC)(O)O[C@@H]4CC)C)=O)[C@H](C(C)C)O—
101036-10AGZ15460.1, AGZ15455.1, (AGZ15456.1/AGZ15469.1), (AGZ15461.1/AGZ15471.1)—
1036-9;Valine
from: 1036-9
O=C(N1[C@@H](C(N(O)C(C)C(N2[C@@H](C(N3[C@H](C(N(O)CC(C(O)=O)C(C)C)=O)[C@@](O)(C)CC3)=O)CCCN2)=O)=O)CCCN1)[C@@H](NC(C(C(CC[C@@H]4C[C@@H](C)CC)(O)O[C@@H]4CC)C)=O)[C@H](C(C)C)O—
111036-11AGZ15460.1TE
1036-10
from: 1036-10
O=C([C@@H](CCCN1)N1C(C(NC([C@H](C)[C@@]2(O)CC[C@H](C[C@@H](C)CC)[C@@]([H])(CC)O2)=O)[C@H](C(C)C)O3)=O)N(O)[C@@H](C)C(N4[C@H](CCCN4)C(N5[C@@H]([C@@](O)(C)CC5)C(N(O)[C@@H](C(C)C)C3=O)=O)=O)=O—
121036-12AGZ15467.1/?—
1036-11
from: 1036-11
O=C([C@@H](CCCN1)N1C(C(NC([C@@](C)(O)[C@@]2(O)CC[C@H](C[C@@H](C)CC)[C@@]([H])(CC)O2)=O)[C@H](C(C)C)O3)=O)N(O)[C@@H](C)C(N4[C@H](CCCN4)C(N5[C@@H]([C@@](O)(C)CC5)C(N(O)[C@@H](C(C)C)C3=O)=O)=O)=O—
131036AGZ15465.1—
1036-12
from: 1036-12
O=C([C@@H](CCCN1)N1C(C(NC([C@@](C)(O)[C@@]2(O)CC[C@H](C[C@@H](C)CC)[C@@]([H])(CC)O2)=O)[C@H](C(C)C)O3)=O)N(O)[C@@H](C)C(N4[C@H](CC(O)CN4)C(N5[C@@H]([C@@](O)(C)CC5)C(N(O)[C@@H](C(C)C)C3=O)=O)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture