NPdia

BGC0001027Hybrid

Nocobactin NA;Nocobactin NA 10152B

Producing organism: Nocardia farcinica IFM 10152
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Mycobacteriales›Nocardiaceae›Nocardia
Biosynthetic class: NRPS (Type I);PKS (Unknown)
Total steps: 10
DOI: 10.1128/JB.00897-10
MIBiG entry: View on MIBiG ↗

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C₃₆H₅₃N₅O₁₀715.38 Da

Biosynthetic (core)

Biosynthetic (additional)

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Ketoreductase (KR)

Acyl carrier (ACP)

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

Acyl carrier (ACP)

Thioesterase (TE)

Epimerization (E)

Heterocyclization (Cy)

10 steps · 9 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`1027-1`	Start	—	Chorismate	`OC1C=CC(C(O)=O)=CC1OC(C(O)=O)=C`	—
2	`1027-2`	?	—	1027-1 from: 1027-1	`OC(C1=CC=CC=C1O)=O`	—
3	`1027-3`	?	—	1027-2 from: 1027-2	`[R]C(C1=CC=CC=C1O)=O`	—
4	`1027-4`	nbtF	—	1027-3;Threonine from: 1027-3	`OC1=C(C2=NC(C(O)=O)=C(C)O2)C=CC=C1`	—
5	`1027-5`	nbtD	—	1027-4;Lysine from: 1027-4	`OC1=C(C2=NC(C(NC(CCCCN)C(O)=O)=O)=C(C)O2)C=CC=C1`	—
6	`1027-6`	nbtB;nbtC, nbtD	—	1027-5;(Caoryl-CoA/Lauryl-CoA) from: 1027-5	`OC1=C(C2=NC(C(NC(CCCCN)C(OC([R])C(C(O)=O)C)=O)=O)=C(C)O2)C=CC=C1`	—
7	`1027-7`	nbtH	—	1027-6;Malonyl-CoA from: 1027-6	`OC1=C(C2=NC(C(NC(CCCCNC(C)=O)C(OC([R])C(C(O)=O)C)=O)=O)=C(C)O2)C=CC=C1`	—
8	`1027-8`	nbtE	—	1027-7;Lysine from: 1027-7	`OC1=C(C2=NC(C(NC(CCCCNC(C)=O)C(OC([R])C(C(N[C@H](CCCCN)C(O)=O)=O)C)=O)=O)=C(C)O2)C=CC=C1`	—
9(1)	`1027(1)`	mbtG, nbtE	—	1027-8 from: 1027-8	`OC1=C(C2=NC(C(NC(CCCCNC(C)=O)C(OC(CCCCCCC)C(C(N[C@@H]3CCCCN(O)C3=O)=O)C)=O)=O)=C(C)O2)C=CC=C1`	—
9(2)	`1027(2)`	mbtG, nbtE	—	1027-8 from: 1027-8	`OC1=C(C2=NC(C(NC(CCCCNC(C)=O)C(OC(CCCCCCCCC)C(C(N[C@@H]3CCCCN(O)C3=O)=O)C)=O)=O)=C(C)O2)C=CC=C1`	—

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