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BGC0001020Hybrid

Muraymycin C1

Producing organism
Streptomyces sp. NRRL 30471
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
17
DOI
MIBiG entry
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muraymycin C1
C38H63N11O17945.44 Da

Gene Cluster Map38 genes · 54,698 bp

ACAAmTACA10 kb54.7 kb visible · 54,698 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
AmTAminotransferase III
TauDTauD oxygenase

Pathway Graphsteps arranged in biosynthetic order

17 steps · 17 edges
Step 1
Start
+L-Arginine
Step 5
mur21
+Leucine
Step 7
mur27, mur14
+Valine
Step 10
Start
+Uridine
Step 12
Start
+Glycine
Step 2
mur16
Step 6
mur16
Step 11
mur22
Step 3
mur15, ?
Step 13
mur17
Step 4
mur12
Step 14
mur24
Step 8
mur12
Step 15
mur23
Step 9
mur21, mur13/mur25
Step 16
(mur22, mur20, mur26, m…
Step 17
mur30
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11020-1Start—
L-Arginine
O=C(O)[C@H](CCCNC(N)=N)N—
21020-2mur16—
1020-1
from: 1020-1
OC(C(N)C(CCNC(N)=N)O)=O—
31020-3mur15, ?—
1020-2
from: 1020-2
N=C1NC(C(N)C(O)=O)CCN1—
41020-4mur12—
1020-3
from: 1020-3
N=C1NC(C(N)C(O)=O)CCN1—
51020-5mur21—
Leucine
OC(C(CC(C)C)N)=C—
61020-6mur16—
1020-5
from: 1020-5
OC(C(C(O)C(C)C)N)=C—
71020-7mur27, mur14—
Valine
NC(C(C)C)C(O)=O—
81020-8mur12—
1020-4;1020-7
from: 1020-4, 1020-7
N=C1NC(C(NC(NC(C(O)=O)C(C)C)=O)C(O)=O)CCN1—
91020-9mur21, mur13/mur25—
1020-6;1020-8
from: 1020-6, 1020-8
N=C1NC(C(C(NC(C(O)=O)C(C(C)C)O)=O)NC(NC(C(O)=O)C(C)C)=O)CCN1—
101020-10Start—
Uridine
O=C1NC(N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C=C1)=O—
111020-11mur22—
1020-10
from: 1020-10
O=C1NC(N([C@@H]2O[C@H](C=O)[C@@H](O)[C@H]2O)C=C1)=O—
121020-12Start—
Glycine
OC(CN)=O—
131020-13mur17—
1020-11;1020-12
from: 1020-11, 1020-12
O=C1NC(N([C@@H]2O[C@H]([C@@H](C(N)C(O)=O)O)[C@@H](O)[C@H]2O)C=C1)=O—
141020-14mur24—
1020-13
from: 1020-13
O=C1NC(N([C@@H]2O[C@H]([C@@H](C(NCC[C@H](C(O)=O)N)C(O)=O)O)[C@@H](O)[C@H]2O)C=C1)=O—
151020-15mur23—
1020-14
from: 1020-14
O=C1NC(N([C@@H]2O[C@H]([C@@H](C(NCCCN)C(O)=O)O)[C@@H](O)[C@H]2O)C=C1)=O—
161020-16(mur22, mur20, mur26, mur18, mur19), mur11—
1020-10;1020-15
from: 1020-10, 1020-15
O=C1NC(N([C@@H]2O[C@H]([C@H](C(NCCCN)C(O)=O)O[C@@H]3O[C@H](CN)[C@@H](O)[C@H]3O)[C@@H](O)[C@H]2O)C=C1)=O—
171020mur30—
1020-9;1020-16
from: 1020-9, 1020-16
O=C1NC(N([C@@H]2O[C@H]([C@H](C(NCCCNC(C(C(C(C)C)O)NC(C(NC(NC(C(O)=O)C(C)C)=O)C3CCNC(N3)=N)=O)=O)C(O)=O)O[C@@H]4O[C@H](CN)[C@@H](O)[C@H]4O)[C@@H](O)[C@H]2O)C=C1)=O—
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