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BGC0001011Hybrid

Meridamycin

Producing organism
Streptomyces sp. NRRL 30748
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
17
DOI
MIBiG entry
View on MIBiG ↗
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meridamycin
C45H75NO12821.53 Da

Gene Cluster Map38 genes · 116,831 bp

20 kb116.8 kb visible · 116,831 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
DnDocking N-term
DcDocking C-term
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

17 steps · 16 edges
Step 1Load
merA
+Malonyl-CoA
Step 2M1
merA
+Methylmalonyl-CoA
Step 3M2
merA
+Methylmalonyl-CoA
Step 4M3
merA
+Malonyl-CoA
Step 5M4
merB
+Ethylmalonyl-CoA
Step 6M5
merB
+Methylmalonyl-CoA
Step 7M6
merB
+Methylmalonyl-CoA
Step 8M7
merB
+Methylmalonyl-CoA
Step 9M8
merC
+Malonyl-CoA
Step 10M9
merC
+Malonyl-CoA
Step 11M10
merC
+Methylmalonyl-CoA
Step 12M11
merC
+Malonyl-CoA
Step 13M12
merC
+Malonyl-CoA
Step 14M13
merC;merD
+Methylmalonyl-CoA
Step 15M14
merD
+Malonyl-CoA
Step 16
merP
+Pipecolic acid
Step 17
merE
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11011-1merALoading
Malonyl-CoA
CC(O)=O—
21011-2merAM1
1011-1;Methylmalonyl-CoA
from: 1011-1
OC([C@H]([C@@H](C)O)C)=O—
31011-3merAM2
1011-2;Methylmalonyl-CoA
from: 1011-2
OC(/C(C)=C/[C@H]([C@@H](C)O)C)=O—
41011-4merAM3
1011-3;Malonyl-CoA
from: 1011-3
OC(C[C@@H](/C(C)=C/[C@H]([C@@H](C)O)C)O)=O—
51011-5merBM4
1011-4;Ethylmalonyl-CoA
from: 1011-4
O[C@H](/C(C)=C/[C@H]([C@@H](C)O)C)C/C=C(CC)/C(O)=O—
61011-6merBM5
1011-5;Methylmalonyl-CoA
from: 1011-5
O[C@H](/C(C)=C/[C@H]([C@@H](C)O)C)C/C=C(CC)/[C@@H](O)C(C)C(O)=O—
71011-7merBM6
1011-6;Methylmalonyl-CoA
from: 1011-6
O[C@H](/C(C)=C/[C@H]([C@@H](C)O)C)C/C=C(CC)/[C@@H](O)C(C)C[C@@H](C(O)=O)C—
81011-8merBM7
1011-7;Methylmalonyl-CoA
from: 1011-7
O[C@H](/C(C)=C/[C@H]([C@@H](C)O)C)C/C=C(CC)/[C@@H](O)C(C)C[C@@H](/C=C(C(O)=O)\C)C—
91011-9merCM8
1011-8;Malonyl-CoA
from: 1011-8
O[C@H](/C(C)=C/[C@H]([C@@H](C)O)C)C/C=C(CC)/[C@@H](O)C(C)C[C@@H](/C=C([C@@H](O)CC(O)=O)\C)C—
101011-10merCM9
1011-9;Malonyl-CoA
from: 1011-9
O[C@H](/C(C)=C/[C@H]([C@@H](C)O)C)C/C=C(CC)/[C@@H](O)C(C)C[C@@H](/C=C([C@@H](O)C[C@H](O)CC(O)=O)\C)C—
111011-11merCM10
1011-10;Methylmalonyl-CoA
from: 1011-10
O[C@H](/C(C)=C/[C@H]([C@@H](C)O)C)C/C=C(CC)/[C@@H](O)C(C)C[C@@H](/C=C([C@@H](O)C[C@H](O)C[C@H](O)[C@@H](C)C(O)=O)\C)C—
121011-12merCM11
1011-11;Malonyl-CoA
from: 1011-11
O[C@H](/C(C)=C/[C@H]([C@@H](C)O)C)C/C=C(CC)/[C@@H](O)C(C)C[C@@H](/C=C([C@@H](O)C[C@H](O)C[C@H](O)[C@@H](C)[C@@H](O)CC(O)=O)\C)C—
131011-13merCM12
1011-12;Malonyl-CoA
from: 1011-12
O[C@H](/C(C)=C/[C@H]([C@@H](C)O)C)C/C=C(CC)/[C@@H](O)C(C)C[C@@H](/C=C([C@@H](O)C[C@H](O)C[C@H](O)[C@@H](C)[C@@H](O)C[C@@H](O)CC(O)=O)\C)C—
141011-14merC;merDM13
1011-13;Methylmalonyl-CoA
from: 1011-13
O[C@H](/C(C)=C/[C@H]([C@@H](C)O)C)C/C=C(CC)/[C@@H](O)C(C)C[C@@H](/C=C([C@@H](O)C[C@H](O)C[C@H](O)[C@@H](C)[C@@H](O)C[C@@H](O)CC[C@H](C(O)=O)C)\C)C—
151011-15merDM14
1011-14;Malonyl-CoA
from: 1011-14
O[C@H](/C(C)=C/[C@H]([C@@H](C)O)C)C/C=C(CC)/[C@@H](O)C(C)C[C@@H](/C=C([C@@H](O)C[C@H](O)C[C@H](O)[C@@H](C)[C@@H](O)C[C@@H](O)CC[C@H](C(CC(O)=O)=O)C)\C)C—
161011-16merP—
1011-15;Pipecolic acid
from: 1011-15
O[C@H](/C(C)=C/[C@H]([C@@H](C)O)C)C/C=C(CC)/[C@@H](O)C(C)C[C@@H](/C=C([C@@H](O)C[C@H](O)C[C@H](O)[C@@H](C)[C@@H](O)C[C@@H](O)CC[C@H](C(CC(N1CCCC[C@H]1C(O)=O)=O)=O)C)\C)C—
171011merE—
1011-16
from: 1011-16
C/C([C@H]1OC([C@H]2N(C(C([C@]3(O)O[C@H](C[C@@H]([C@@H]([C@H](C[C@H](C[C@H](O)/C(C)=C\[C@@H](C)CC(C)[C@H](O)/C(CC)=C/C1)O)O)C)O)CC[C@H]3C)=O)=O)CCCC2)=O)=C\[C@@H](C)[C@H](O)C—
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