NPdia

BGC0001006Hybrid

Lymphostin;Neolymphostinol B;Lymphostinol;Neolymphostin B

Producing organism: Salinispora tropica CNB-440
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Salinispora
Biosynthetic class: NRPS (Type I);PKS (Unknown)
Total steps: 11
DOI: 10.1021/ja205655w
MIBiG entry: View on MIBiG ↗

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C₁₆H₁₄N₄O₃310.11 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Acyl carrier protein (ACP)

Methyltransferase

Terminal reductase

CoA-ligase (CAL)

11 steps · 10 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`1006-1`	Start	—	Tryptophan	`[NH3+][C@H](C([O-])=O)CC1=CNC2=CC=CC=C21`	—
2	`1006-2`	?	—	1006-1 from: 1006-1	`NC1=CC(N)=C2C3=C1N=C(C([O-])=O)C=C3C=N2`	—
3	`1006-3`	?	—	1006-2 from: 1006-2	`NC1=CC(N)=C2C3=C1N=C(C(O)=O)C=C3C=N2`	—
4	`1006-4`	Strop_3056	—	1006-3;Malonyl-CoA from: 1006-3	`NC1=CC(N)=C2C3=C1N=C(C(CC(O)=O)=O)C=C3C=N2`	—
5	`1006-5`	?	—	1006-4 from: 1006-4	`O=C(CC=O)C1=NC2=C(C3=C1)C(N=C3)=C(N)C=C2NC([R])=O`	—
6	`1006-6`	Strop_3055	—	1006-5 from: 1006-5	`O=C(/C=C/OC)C1=NC2=C(C3=C1)C(N=C3)=C(N)C=C2NC([R])=O`	—
7	`1006(1)`	Strop_3055	—	1006-5 from: 1006-5	`O=C(/C=C/OC)C1=NC2=C(C3=C1)C(N=C3)=C(N)C=C2NC(C)=O`	—
8	`1006(2)`	Strop_3055	—	1006-5 from: 1006-5	`O=C(/C=C/OC)C1=NC2=C(C3=C1)C(N=C3)=C(N)C=C2NC(CC)=O`	—
9	`1006-7`	?	—	1006-4 from: 1006-4	`O=C(CCO)C1=NC2=C(C3=C1)C(N=C3)=C(N)C=C2NC([R])=O`	—
10	`1006(3)`	?	—	1006-4 from: 1006-4	`O=C(CCO)C1=NC2=C(C3=C1)C(N=C3)=C(N)C=C2NC(C)=O`	—
11	`1006(4)`	?	—	1006-4 from: 1006-4	`O=C(CCO)C1=NC2=C(C3=C1)C(N=C3)=C(N)C=C2NC(CC)=O`	—

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