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BGC0001004PKS

Lobophorin B

Producing organism
Streptomyces sp. SCSIO 01127
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
38
DOI
MIBiG entry
View on MIBiG ↗
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lobophorin B
C61H90N2O211186.60 Da

Gene Cluster Map36 genes · 98,567 bp

20 kb98.6 kb visible · 98,567 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
AmTAminotransferase V
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

38 steps · 39 edges
Step 1Load
lobA5
+Malonyl-CoA
Step 15
Start
Step 22
Start
Step 2M1
lobA5
+Methylmalonyl-CoA
Step 16
lobC3;lobC2
Step 23
lobS9
Step 3M2
lobA5
+Malonyl-CoA
Step 17
lobC1
Step 24
lobS8
Step 4M3
lobA5
+Methylmalonyl-CoA
Step 25
lobS4
Step 5M4
lobA4
+Malonyl-CoA
Inactive: DH
Step 26
lobS6
Step 33
lobS10
Step 6M5
lobA4
+Methylmalonyl-CoA
Step 27
lobS5
Step 34
lobS11
Step 7M6
lobA4
+Malonyl-CoA
Step 28
lobS7
Step 35
?
Step 8M7
lobA4
+Malonyl-CoA
Step 29
lobS2
Step 9M8
lobA3
+Methylmalonyl-CoA
Inactive: DH
Step 30
lobS3
Step 10M9
lobA1
+Methylmalonyl-CoA
Step 31
lobP2
Step 11M10
lobA1
+Methylmalonyl-CoA
Step 32
?
Step 12M11
lobA2
+Malonyl-CoA
Inactive: KR
Step 13
?
Step 14
?
Step 18
lobC4
Step 19
lobC1
Step 20
lobP3
Step 21
lobP3
Step 36
lobG1
Step 37
lobG3
Step 38
lobG2, lobS1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions38 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11004-1lobA5Loading
Malonyl-CoA
O=C(C)O—
21004-2lobA5M1
1004-1;Methylmalonyl-CoA
from: 1004-1
C/C=C(C)/C(O)=O—
31004-3lobA5M2
1004-2;Malonyl-CoA
from: 1004-2
C/C=C(C)/C=C/C(O)=O—
41004-4lobA5M3
1004-3;Methylmalonyl-CoA
from: 1004-3
C/C=C(C)/C=C/C=C(C)/C(O)=O—
51004-5lobA4M4
1004-4;Malonyl-CoA
from: 1004-4
C/C=C(C)/C=C/C=C(C)/[C@H](O)CC(O)=O{'Inactive': ['DH']}
61004-6lobA4M5
1004-5;Methylmalonyl-CoA
from: 1004-5
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C(O)=O—
71004-7lobA4M6
1004-6;Malonyl-CoA
from: 1004-6
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C(O)=O—
81004-8lobA4M7
1004-7;Malonyl-CoA
from: 1004-7
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C=C/C(O)=O—
91004-9lobA3M8
1004-8;Methylmalonyl-CoA
from: 1004-8
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C=C/[C@H](O)[C@H](C(O)=O)C{'Inactive': ['DH']}
101004-10lobA1M9
1004-9;Methylmalonyl-CoA
from: 1004-9
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C=C/[C@H](O)[C@H](C[C@@H](C(O)=O)C)C—
111004-11lobA1M10
1004-10;Methylmalonyl-CoA
from: 1004-10
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C=C/[C@H](O)[C@H](C[C@@H](/C=C(C(O)=O)\C)C)C—
121004-12lobA2M11
1004-11;Malonyl-CoA
from: 1004-11
C/C=C(C)/C=C/C=C(C)/[C@H](O)C/C=C(C)/C=C/C=C/[C@H](O)[C@H](C[C@@H](/C=C(C(CC(O)=O)=O)\C)C)C{'Inactive': ['KR']}
131004-13?—
1004-12
from: 1004-12
O=C(CC(O)=O)/C(C)=C/[C@@H](C)C[C@H](C)[C@H](O)/C=C/C=C/C(C)=C/C[C@H](O)/C(C)=C/C=C/C(C)=C/C—
141004-14?—
1004-13
from: 1004-13
O=C(CC(O)=O)[C@]1(C)[C@](C=C[C@]2([H])[C@@H](O)[C@@H](C)C[C@H](C)[C@]21[H])([H])/C(C)=C/C[C@H](O)/C(C)=C/C=C/C(C)=C/C—
151004-15Start—
O[C@H](COP(O)(O)=O)C(OP(O)(O)=O)=O—
161004-16lobC3;lobC2—
1004-15
from: 1004-15
O[C@H](CO)C(O)=O—
171004-17lobC1—
1004-16
from: 1004-16
O[C@H](CO)C([R])=O—
181004-18lobC4—
1004-14;1004-17
from: 1004-14, 1004-17
O=C(/C(C(O)=O)=C(O)/C(CO)O)[C@]1(C)[C@](C=C[C@]2([H])[C@@H](O)[C@@H](C)C[C@H](C)[C@]21[H])([H])/C(C)=C/C[C@H](O)/C(C)=C/C=C/C(C)=C/C—
191004-19lobC1—
1004-18
from: 1004-18
O=C(C1=C(O)C(CO)OC1=O)[C@]2(C)[C@](C=C[C@]3([H])[C@@H](O)[C@@H](C)C[C@H](C)[C@]32[H])([H])/C(C)=C/C[C@H](O)/C(C)=C/C=C/C(C)=C/C—
201004-20lobP3—
1004-19
from: 1004-19
O=C(C(C(O1)=O)=C(O)C1=C)[C@]2(C)[C@](C=C[C@]3([H])[C@@H](O)[C@@H](C)C[C@H](C)[C@]32[H])([H])/C(C)=C/C[C@H](O)/C(C)=C/C=C/C(C)=C/C—
211004-21lobP3—
1004-20
from: 1004-20
O=C(C(C(O1)=O)=C2O)[C@]3(C)[C@](C=C[C@]4([H])[C@@H](O)[C@@H](C)C[C@H](C)[C@]43[H])([H])/C(C)=C/C[C@H](O)/C(C)=C/[C@@](C=C5C)([H])[C@@]21C[C@H]5C—
221004-22Start—
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
231004-23lobS9—
1004-22
from: 1004-22
O[C@H]1[C@H](O)[C@@H](O)[C@@H]([R])O[C@@H]1CO—
241004-24lobS8—
1004-23
from: 1004-23
O[C@H]([C@@H](O)[C@@H]([R])O[C@@H]1C)C1=O—
251004-25lobS4—
1004-24
from: 1004-24
[R][C@@H](O[C@@H]1C)CC(C1=O)=O—
261004-26lobS6—
1004-25
from: 1004-25
[R][C@@H](O[C@@H]1C)C[C@@H](N)C1=O—
271004-27lobS5—
1004-26
from: 1004-26
[R][C@@H](O[C@@H]1C)C[C@](C)(N)C1=O—
281004-28lobS7—
1004-27
from: 1004-27
[R][C@@H](O[C@@H]1C)C[C@](C)([N+]([O-])=O)C1=O—
291004-29lobS2—
1004-28
from: 1004-28
[R][C@@H]1C[C@](C)([N+]([O-])=O)[C@@H](N)[C@@H](C)O1—
301004-30lobS3—
1004-29
from: 1004-29
[R][C@@H]1C[C@](C)([N+]([O-])=O)[C@@H](NC)[C@@H](C)O1—
311004-31lobP2—
1004-30
from: 1004-30
[R][C@@H]1C[C@](C)([N+]([O-])=O)[C@@H](NC(O)=O)[C@@H](C)O1—
321004-32?—
1004-31
from: 1004-31
[R][C@@H]1C[C@](C)([N+]([O-])=O)[C@@H](NC(OC)=O)[C@@H](C)O1—
331004-33lobS10—
1004-25
from: 1004-25
[R][C@@H](O[C@@H]1C)C[C@@H](O)C1=O—
341004-34lobS11—
1004-33
from: 1004-33
[R][C@@H]1C[C@@H](O)C([C@H](C)O1)=O—
351004-35?—
1004-34
from: 1004-34
[R][C@@H]1C[C@@H](O)[C@@H](O)[C@H](C)O1—
361004-36lobG1—
1004-21;1004-32
from: 1004-21, 1004-32
O=C(C(C(O1)=O)=C2O)[C@]3(C)[C@](C=C[C@]4([H])[C@@H](O)[C@@H](C)C[C@H](C)[C@]43[H])([H])/C(C)=C/C[C@H](O[C@H]5C[C@](C)([N+]([O-])=O)[C@@H](NC(OC)=O)[C@@H](C)O5)/C(C)=C/[C@@](C=C6C)([H])[C@@]21C[C@H]6C—
371004-37lobG3—
1004-35;1004-35;1004-36
from: 1004-35, 1004-35, 1004-36
O=C(C(C(O1)=O)=C2O)[C@]3(C)[C@](C=C[C@]4([H])[C@@H](O[C@H]5C[C@@H](O[C@H]6C[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](C)O5)[C@@H](C)C[C@H](C)[C@]43[H])([H])/C(C)=C/C[C@H](O[C@H]7C[C@](C)([N+]([O-])=O)[C@@H](NC(OC)=O)[C@@H](C)O7)/C(C)=C/[C@@](C=C8C)([H])[C@@]21C[C@H]8C—
381004lobG2, lobS1—
1004-35;1004-37
from: 1004-35, 1004-37
O=C(C(C(O1)=O)=C2O)[C@]3(C)[C@](C=C[C@]4([H])[C@@H](O[C@H]5C[C@@H](O[C@H]6C[C@@H](O)[C@@H](O[C@@H]7C[C@@H](O)[C@@H](OC)[C@H](C)O7)[C@H](C)O6)[C@@H](O)[C@H](C)O5)[C@@H](C)C[C@H](C)[C@]43[H])([H])/C(C)=C/C[C@H](O[C@H]8C[C@](C)([N+]([O-])=O)[C@@H](NC(OC)=O)[C@@H](C)O8)/C(C)=C/[C@@](C=C9C)([H])[C@@]21C[C@H]9C—
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