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BGC0001003Hybrid

α-lipomycin

Producing organism
Kitasatospora aureofaciens
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Kitasatospora
Biosynthetic class
NRPS (Type I);PKS (Type I);saccharide (hybrid/tailoring)
Total steps
18
DOI
MIBiG entry
View on MIBiG ↗
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α-lipomycin
C32H45NO9587.31 Da

Gene Cluster Map22 genes · 66,871 bp

KSKSKSKSKSKSKS10 kb66.9 kb visible · 66,871 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1Load
lipPks1
+Isobutyl-CoA
Step 12
Start
Step 2M1
lipPks1
+Methylmalonyl-CoA
Step 13
lipDig1
Step 3M2
lipPks2
+Methylmalonyl-CoA
Step 14
lipDig2
Step 4M3
lipPks2
+Malonyl-CoA
Step 15
lipDig5
Step 5M4
lipPks3
+Malonyl-CoA
Step 16
lipDig3
Step 6M5
lipPks3
+Malonyl-CoA
Step 17
lipDig4
Step 7M6
lipPks4
+Malonyl-CoA
Step 8M7
lipPks4
+Malonyl-CoA
Step 9
lipNrps
+Glutamic acid
Step 10
?
Step 11
?
Step 18
lipGtf
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11003-1lipPks1Loading
Isobutyl-CoA
CC(C(O)=O)C—
21003-2lipPks1M1
1003-1;Methylmalonyl-CoA
from: 1003-1
CC(C(O)C(C(O)=O)C)C—
31003-3lipPks2M2
1003-2;Methylmalonyl-CoA
from: 1003-2
CC(C(O)C(/C=C(C(O)=O)\C)C)C—
41003-4lipPks2M3
1003-3;Malonyl-CoA
from: 1003-3
CC(C(O)C(/C=C(/C=C/C(O)=O)C)C)C—
51003-5lipPks3M4
1003-4;Malonyl-CoA
from: 1003-4
CC(C(O)C(/C=C(/C=C/C=C/C(O)=O)C)C)C—
61003-6lipPks3M5
1003-5;Malonyl-CoA
from: 1003-5
CC(C(O)C(/C=C(/C=C/C=C/C=C/C(O)=O)C)C)C—
71003-7lipPks4M6
1003-6;Malonyl-CoA
from: 1003-6
CC(C(O)C(/C=C(/C=C/C=C/C=C/C=C/C(O)=O)C)C)C—
81003-8lipPks4M7
1003-7;Malonyl-CoA
from: 1003-7
CC(C(O)C(/C=C(/C=C/C=C/C=C/C=C/C(CC(O)=O)=O)C)C)C—
91003-9lipNrps—
1003-8;Glutamic acid
from: 1003-8
O=C(CC(/C=C/C=C/C=C/C=C/C(C)=C/C(C(C(C)C)O)C)=O)N(C(C(O)=O)CCC(O)=O)C—
101003-10?—
1003-9
from: 1003-9
O=C(/C=C/C=C/C=C/C=C/C(C)=C/C(C(C(C)C)O)C)C1C(N(C)C(CCC(O)=O)C1=O)=O—
111003-11?—
1003-10
from: 1003-10
OC(C(N1C)CCC(O)=O)=C(C(/C=C/C=C/C=C/C=C/C(C)=C/C(C)C(O)C(C)C)=O)C1=O—
121003-12Start—
O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1[R]—
131003-13lipDig1—
1003-12
from: 1003-12
O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1[R]—
141003-14lipDig2—
1003-13
from: 1003-13
O[C@@H]([C@@H]([R])O[C@@H]1C)[C@@H](O)C1=O—
151003-15lipDig5—
1003-14
from: 1003-14
[R][C@@H](O[C@@H]1C)CC(C1=O)=O—
161003-16lipDig3—
1003-15
from: 1003-15
[R][C@@H](O[C@@H]1C)C[C@H](O)C1=O—
171003-17lipDig4—
1003-16
from: 1003-16
[R][C@@H]1C[C@H](O)[C@H](O)[C@@H](C)O1—
181003lipGtf—
1003-11;1003-17
from: 1003-11, 1003-17
OC(C(N1C)CCC(O)=O)=C(C(/C=C/C=C/C=C/C=C/C(C)=C/C(C)C(O)C(C(C(C)C)O[C@@]2([H])O[C@@H](C)[C@H](O)[C@H](O)C2)C)=O)C1=O—
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