NPdia

BGC0000998Hybrid

Guadinomine;Guadinomine B;Guadinomic acid

Producing organism: Streptomyces sp. K01-0509
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I);PKS (Unknown)
Total steps: 17
DOI: 10.1021/ja308622d
MIBiG entry: View on MIBiG ↗

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Transport

Other

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Dehydratase (DH)

Enoylreductase (ER)

Ketoreductase (KR)

Acyl carrier protein (ACP)

Acyl carrier (ACP)

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

Acyl carrier (ACP)

Thioesterase (TE)

LPG synthase C

ACP synthase

Aminotransferase III

17 steps · 16 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`998-1`	Start	—	Arginine	`N/C(NCCC[C@@H](C(O)=O)N)=N/[H]`	—
2	`998-2`	gdnJ, ?	—	998-1 from: 998-1	`O/C(N)=N/[H]`	—
3	`998-3`	Start	—	Glycine	`OC(CN)=O`	—
4	`998-4`	?	—	998-2;998-3 from: 998-2, 998-3	`N=C(N)NCC(O)=O`	—
5	`998-5`	gdnE	—	998-4 from: 998-4	`N=C(N)NCC(O)=O`	—
6	`998-6`	gdnE	—	998-5;Malonyl-CoA from: 998-5	`N=C(N)NC/C=C/C(O)=O`	—
7	`998-7`	gdnF	—	998-6;Malonyl-CoA from: 998-6	`O[C@H](CC(O)=O)C[C@@H]1CN(C(N)=O)C(N1)=N`	—
8	`998-8`	gdnG	—	998-7;Malonyl-CoA from: 998-7	`O[C@H](CCCC(O)=O)C[C@@H]1CN(C(N)=O)C(N1)=N`	—
9	`998(1)`	gdnT	—	998-8 from: 998-8	`O[C@H](CCCC(O)=O)C[C@@H]1CN(C(N)=O)C(N1)=N`	—
10	`998-9`	Start	—	L-Serine	`N[C@@H](CO)C(O)=O`	—
11	`998-10`	gdnC, gdnB	—	998-9 from: 998-9	`N[C@@H](CO)C(O)=O`	—
12	`998-11`	gdnD	—	998-10 from: 998-10	`N[C@@H](C([H])=O)C(O)=O`	—
13	`998-12`	gdnA	—	998-11 from: 998-11	`NC(C(O)=O)C(O)=O`	—
14	`998-13`	gdnH	—	998-8;998-12 from: 998-8, 998-12	`O[C@H](CCC[C@H](N)[C@H](N)C(O)=O)C[C@@H]1CN(C(N)=O)C(N1)=N`	—
15	`998-14`	gdnT	—	998-13;Alanine;Valine from: 998-13	`O=C(N)N1C(N[C@H](C[C@H](O)CCC[C@H](N)[C@@H](C(N[C@H](C(N[C@H](C(O)=O)C(C)C)=O)C)=O)N)C1)=N`	—
16	`998(2)`	gdnI	—	998-14 from: 998-14	`O=C(N)N1C(N[C@H](C[C@H](O)[C@H](O)CC[C@H](N)[C@@H](C(N[C@H](C(N[C@H](C(O)=O)C(C)C)=O)C)=O)N)C1)=N`	—
17	`998(3)`	?	—	998(2)	`O=C(N)N1C(N[C@H](C(O)[C@H](O)[C@H](O)CC[C@H](N)[C@@H](C(N[C@H](C(N[C@H](C(O)=O)C(C)C)=O)C)=O)N)C1)=N`	—

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