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BGC0000994Hybrid

FR-900520

Producing organism
Streptomyces hygroscopicus subsp. ascomyceticus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces violaceusniger group
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
13
DOI
MIBiG entry
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FR-900520
C43H69NO12791.48 Da

Gene Cluster Map22 genes · 77,534 bp

KSKSCALKSKSKSKSAKSKSKSKS20 kb77.5 kb visible · 77,534 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
CALCoA-ligase (CAL)

Pathway Graphsteps arranged in biosynthetic order

13 steps · 12 edges
Step 1Load
fkbB
Step 2M1
fkbB
+Methylmalonyl-CoA
Step 3M2
fkbB
+Methylmalonyl-CoA
Inactive: DH
Step 4M3
fkbB
+Malonyl-CoA
Inactive: DH
Step 5M4
fkbB
+Ethylmalonyl-CoA
Inactive: DH
Step 6M5
fkbC
+Methylmalonyl-CoA
Step 7M6
fkbA
+Methylmalonyl-CoA
Step 8M7
fkbA
+Methoxymalonyl-ACP
Step 9M8
fkbA
+Methoxymalonyl-ACP
Inactive: DH
Step 10M9
fkbA
+Methylmalonyl-CoA
Step 11M10
fkbA
+Malonyl-CoA
Step 12
fkbP
+Pipecolic acid
Step 13
(fkbD;fkbO),fkbM
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1994-1fkbBLoading
OC1[C@H](O)CCC(C(O)=O)C1—
2994-2fkbBM1
994-1;Methylmalonyl-CoA
from: 994-1
OC1[C@H](O)CCC(/C=C(C(O)=O)\C)C1—
3994-3fkbBM2
994-2;Methylmalonyl-CoA
from: 994-2
OC1[C@H](O)CCC(/C=C([C@@H](O)[C@@H](C(O)=O)C)\C)C1{'Inactive': ['DH']}
4994-4fkbBM3
994-3;Malonyl-CoA
from: 994-3
OC1[C@H](O)CCC(/C=C([C@@H](O)[C@@H]([C@@H](O)CC(O)=O)C)\C)C1{'Inactive': ['DH']}
5994-5fkbBM4
994-4;Ethylmalonyl-CoA
from: 994-4
OC1[C@H](O)CCC(/C=C([C@@H](O)[C@@H]([C@@H](O)CC([C@@H](C(O)=O)CC)=O)C)\C)C1{'Inactive': ['DH']}
6994-6fkbCM5
994-5;Methylmalonyl-CoA
from: 994-5
OC1[C@H](O)CCC(/C=C([C@@H](O)[C@@H]([C@@H](O)CC([C@@H](/C=C(C(O)=O)\C)CC)=O)C)\C)C1—
7994-7fkbAM6
994-6;Methylmalonyl-CoA
from: 994-6
OC1[C@H](O)CCC(/C=C([C@@H](O)[C@@H]([C@@H](O)CC([C@@H](/C=C(C[C@@H](C(O)=O)C)\C)CC)=O)C)\C)C1—
8994-8fkbAM7
994-7;Methoxymalonyl-ACP
from: 994-7
OC1[C@H](O)CCC(/C=C([C@@H](O)[C@@H]([C@@H](O)CC([C@@H](/C=C(C[C@@H](C[C@@H](C(O)=O)OC)C)\C)CC)=O)C)\C)C1—
9994-9fkbAM8
994-8;Methoxymalonyl-ACP
from: 994-8
OC1[C@H](O)CCC(/C=C([C@@H](O)[C@@H]([C@@H](O)CC([C@@H](/C=C(C[C@@H](C[C@@H]([C@@H](O)[C@H](C(O)=O)OC)OC)C)\C)CC)=O)C)\C)C1{'Inactive': ['DH']}
10994-10fkbAM9
994-9;Methylmalonyl-CoA
from: 994-9
OC1[C@H](O)CCC(/C=C([C@@H](O)[C@@H]([C@@H](O)CC([C@@H](/C=C(C[C@@H](C[C@@H]([C@@H](O)[C@H](C[C@H](C(O)=O)C)OC)OC)C)\C)CC)=O)C)\C)C1—
11994-11fkbAM10
994-10;Malonyl-CoA
from: 994-10
OC1[C@H](O)CCC(/C=C([C@@H](O)[C@@H]([C@@H](O)CC([C@@H](/C=C(C[C@@H](C[C@@H]([C@@H](O)[C@H](C[C@H](C(CC(O)=O)=O)C)OC)OC)C)\C)CC)=O)C)\C)C1—
12994-12fkbP—
994-11;Pipecolic acid
from: 994-11
OC1[C@H](O)CCC(/C=C([C@@H](O)[C@@H]([C@@H](O)CC([C@@H](/C=C(C[C@@H](C[C@@H]([C@@H](O)[C@H](C[C@H](C(CC(N2C(C(O)=O)CCCC2)=O)=O)C)OC)OC)C)\C)CC)=O)C)\C)C1—
13994(fkbD;fkbO),fkbM—
994-12
from: 994-12
O=C(N1[C@H]2CCCC1)C([C@]3(O)O[C@H]([C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H](C(C[C@@H]([C@@H](C)[C@@H](/C(C)=C/C4CC[C@@H](O)[C@H](OC)C4)OC2=O)O)=O)CC)[C@@H](OC)C[C@H]3C)=O—
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