NPdia

BGC0000973Hybrid

Collismycin A

Producing organism: Streptomyces sp. CS40
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I);PKS (Type I)
Total steps: 17
DOI: 10.1016/j.chembiol.2012.01.014
MIBiG entry: View on MIBiG ↗

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collismycin A

C₁₃H₁₃N₃O₂S275.07 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Transport

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

COM N-term

COM C-term

Thioesterase (TE)

Heterocyclization (Cy)

Methyltransferase

Aminotransferase III

17 steps · 16 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`973-1`	Start	—		`N[C@H](C(O)=O)CCCCN`	—
2	`973-2`	clmL	—	973-1 from: 973-1	`NCCCCC(C(O)=O)=O`	—
3	`973-3`	?	—	973-2 from: 973-2	`OC(C1=NCCCC1)=O`	—
4	`973-4`	clmS	—	973-3 from: 973-3	`OC(C1=NC=CC=C1)=O`	—
5	`973-5`	clmAL	—	973-4 from: 973-4	`[R]C(C1=NC=CC=C1)=O`	—
6	`973-6`	clmP, clmN1	—	973-5 from: 973-5	`OC(C1=NC=CC=C1)=O`	—
7	`973-7`	clmN1	—	973-6;Malonyl-CoA from: 973-6	`O=C(CC(O)=O)C1=NC=CC=C1`	—
8	`973-8`	?	—	973-7 from: 973-7	`OC(CC(O)=O)C1=NC=CC=C1`	—
9	`973-9`	?	—	973-8 from: 973-8	`O=C(O)/C=C/C1=NC=CC=C1`	—
10	`973-10`	clmN1	—	973-9;Cysteine, CoA? from: 973-9	`O=C([R])/C=C(NC(CS)C(O)=O)/C1=NC=CC=C1`	—
11	`973-11`	clmN2	—	973-10;Leucine from: 973-10	`O=C([R])/C=C(NC(CS)C(NC(C(O)=O)CC(C)C)=O)/C1=NC=CC=C1`	—
12	`973-12`	clmT, clmD1?, clmD2?, clmM?, ?	—	973-11 from: 973-11	`O=C1C2=NC(C3=NC=CC=C3)=CC(O)=C2SN1C(C(O)=O)CC(C)C`	—
13	`973-13`	clmM1	—	973-12 from: 973-12	`O=C(NC(C(O)=O)CC(C)C)C1=NC(C2=NC=CC=C2)=CC(O)=C1SC`	—
14	`973-14`	clmAH	—	973-13 from: 973-13	`OC(C1=NC(C2=NC=CC=C2)=CC(O)=C1SC)=O`	—
15	`973-15`	clmG1, clmG2	—	973-14 from: 973-14	`[H]C(C1=NC(C2=NC=CC=C2)=CC(O)=C1SC)=O`	—
16	`973-16`	clmAT	—	973-15 from: 973-15	`OC1=C(SC)C(/C=N/O)=NC(C2=NC=CC=C2)=C1`	—
17	`973`	clmM2	—	973-16 from: 973-16	`CSC1=C(OC)C=C(N=C1/C=N/O)C2=NC=CC=C2`	—

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