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BGC0000971Hybrid

Cinnabaramide A

Producing organism
Streptomyces cinnabarigriseus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Type I)
Total steps
6
DOI
MIBiG entry
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cinnabaramide A
C19H29NO4335.21 Da

Gene Cluster Map22 genes · 29,932 bp

CALAAmTKSATATCAKSTdER5 kb29.9 kb visible · 29,932 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
EREnoylreductase (ER)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TdTrans-AT docking
CALCoA-ligase (CAL)
AmTAminotransferase IV

Pathway Graphsteps arranged in biosynthetic order

6 steps · 5 edges
Step 1
Start
Step 2
cinF
Step 3M0;1
cinA
+Malonyl-CoA
Step 4
cinB
+Cyclohexenylalani…
Step 5
cinE, cinC
Step 5
cinD
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions6 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1971-1Start—
O=C([R])/C=C/CCCCC—
2971-2cinF—
971-1
from: 971-1
O=C([R])C(CCCCCC)C(C)=O—
3971-3cinAM0;1
971-2;Malonyl-CoA
from: 971-2
CC(C(C(O)=O)CCCCCC)=O—
4971-4cinB—
971-3;Cyclohexenylalanine
from: 971-3
CC(C(C(NC(CC1C=CCCC1)C(O)=O)=O)CCCCCC)=O—
5971-5cinE, cinC—
971-4
from: 971-4
O=C1N[C@@]([C@H]([C@]2([H])C=CCCC2)O)(C(O)=O)[C@](O)(C)[C@]1(CCCCCC)[H]—
5971cinD—
971-5
from: 971-5
O=C1N[C@@]([C@H]([C@]2([H])C=CCCC2)O)(C3=O)[C@@](C)(O3)[C@]1(CCCCCC)[H]—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture