NPdia

BGC0000966Hybrid

Caerulomycin A

Producing organism: Actinoalloteichus sp. WH1-2216-6
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Actinoalloteichus
Biosynthetic class: NRPS (Type I);PKS (Unknown)
Total steps: 13
DOI: 10.1021/ol300589r
MIBiG entry: View on MIBiG ↗

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caerulomycin A

C₁₂H₁₁N₃O₂229.09 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Transport

Other

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

COM N-term

Thioesterase (TE)

Heterocyclization (Cy)

Aminotransferase III

Aminotransferase V

13 steps · 12 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`966-1`	Start	—	L-lysine	`NC(CCCC[NH3+])C(O)=O`	—
2	`966-2`	AFD30956.1	—	966-1 from: 966-1	`OC(C1=NCCCC1)=O`	—
3	`966-3`	AFD30955.1	—	966-2 from: 966-2	`OC(C1=NC=CC=C1)=O`	—
4	`966-4`	AFD30957.1	Loading	966-3 from: 966-3	`O=C(O)C1=NC=CC=C1`	—
5	`966-5`	AFD30954.1	M1	966-4;Malonyl-CoA from: 966-4	`O=C(CC(O)=O)C1=NC=CC=C1`	—
6	`966-6`	AFD30954.1	M2	966-5;Serine from: 966-5	`OC1=CC(C2=NC=CC=C2)=NC(C(O)=O)=C1`	—
7	`966-7`	AFD30953.1	M3	966-6;Leucine from: 966-6	`OC1=CC(C2=NC=CC=C2)=NC(C(N[C@H](C(O)=O)CC(C)C)=O)=C1`	—
8	`966-8`	AFD30951.1	TE	966-7 from: 966-7	`OC1=CC(C2=NC=CC=C2)=NC(C(N[C@H](C(O)=O)CC(C)C)=O)=C1`	—
9	`966-9`	AFD30949.1	—	966-8 from: 966-8	`OC1=CC(C2=NC=CC=C2)=NC(C(O)=O)=C1`	—
10	`966-10`	AFD30948.1/AFD30947.1	—	966-9 from: 966-9	`OC1=CC(C2=NC=CC=C2)=NC(C([H])=O)=C1`	—
11	`966-11`	AFD30959.1	—	966-10 from: 966-10	`OC1=CC(C2=NC=CC=C2)=NC(CN)=C1`	—
12	`966-12`	AFD30961.1	—	966-11 from: 966-11	`OC1=CC(C2=NC=CC=C2)=NC(C=NO)=C1`	—
13	`966`	AFD30960.1	—	966-12 from: 966-12	`ON=CC1=CC(OC)=CC(C2=NC=CC=C2)=N1`	—

Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture