NPdia
← Back to Repository
BGC0000960Hybrid

Azinomycin B

Producing organism
Streptomyces sahachiroi
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
26
DOI
MIBiG entry
View on MIBiG ↗
Loading…
azinomycin B
C31H33N3O11623.21 Da

Gene Cluster Map47 genes · 63,538 bp

CALAACAKS10 kb63.5 kb visible · 63,538 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
TDTerminal reductase
CALCoA-ligase (CAL)

Pathway Graphsteps arranged in biosynthetic order

26 steps · 25 edges
Step 1
Start
Step 6
Start
Step 8
Start
Step 25
Start
Step 2
azi26
{'iteration': [((None), ‘M…
Step 7
azi31
Step 9
azi30
Step 3
?
Step 10
azi22
Step 4
azi6
Step 11
azi21
Step 5
azi5
Step 12
azi17/azi18
Step 13
?
Step 19
azi7
Step 14
azi19
Step 20
azi9
Step 15
azi24
Step 21
azi1
Step 16
?
Step 17
azi32;?
Step 18
azi23
Step 22
azi3
Step 23
azi25
+Threonine
Step 24
?
Step 26
azi34, azi35, azi15
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions26 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1960-1Start—
[R]C(C)=O—
2960-2azi26—
960-1
from: 960-1
OC(CC(CC(CC(O)CC([R])=O)O)=O)CC(C)=O{'iteration': [((None), ‘Mal…
3960-3?—
960-2
from: 960-2
OC(C1=C2C(C(C)=CC=C2)=CC=C1)=O—
4960-4azi6—
960-3
from: 960-3
OC(C1=C2C(C(C)=CC=C2)=CC(O)=C1)=O—
5960-5azi5—
960-4
from: 960-4
OC(C1=C2C(C(C)=CC=C2)=CC(OC)=C1)=O—
6960-6Start—
CC(C)[C@@H](C(O)=O)N—
7960-7azi31—
960-6
from: 960-6
CC(C)C(C(O)=O)=O—
8960-8Start—
OC([C@@H](N)CCC(O)=O)=O—
9960-9azi30—
960-8
from: 960-8
OC([C@@H](NC(C)=O)CCC(O)=O)=O—
10960-10azi22—
960-9
from: 960-9
OC([C@@H](NC(C)=O)CCC(OP([O-])([O-])=O)=O)=O—
11960-11azi21—
960-10
from: 960-10
OC([C@@H](NC(C)=O)CCC([H])=O)=O—
12960-12azi17/azi18—
960-11
from: 960-11
OC([C@@H](NC(C)=O)CC[C@@H](C(O)(CO)[R])O)=O—
13960-13?—
960-12
from: 960-12
OC([C@@H](NC(C)=O)CC[C@@H](C(CO)=O)O)=O—
14960-14azi19—
960-13
from: 960-13
OC([C@@H](NC(C)=O)CC[C@@H]([C@@H](N)CO)O)=O—
15960-15azi24—
960-14
from: 960-14
OC(/C(NC(C)=O)=C\C[C@@H]([C@@H](N)CO)O)=O—
16960-16?—
960-15
from: 960-15
OC([C@@H](NC(C)=O)C1C[C@H](O)[C@H](CO)N1)=O—
17960-17azi32;?—
960-16
from: 960-16
OC(/C(NC(C)=O)=C1[C@@H](O)[C@H](O)[C@H]2N/1C2)=O—
18960-18azi23—
960-17
from: 960-17
OC(/C(N)=C1[C@@H](O)[C@H](O)[C@H]2N/1C2)=O—
19960-19azi7—
960-5
from: 960-5
OC(C1=C2C(C(C)=CC=C2)=CC(OC)=C1)=O—
20960-20azi9—
960-19
from: 960-19
OC(C1=C2C(C(C)=CC=C2)=CC(OC)=C1)=O—
21960-21azi1—
960-20;960-7
from: 960-20, 960-7
O=C(O[C@H](C(O)=O)C(C)C)C1=C2C(C(C)=CC=C2)=CC(OC)=C1—
22960-22azi3—
960-21;960-18
from: 960-21, 960-18
O[C@H]1[C@@H]([C@@H]2CN2/C1=C(NC([C@H](C(C)C)OC(C3=CC(OC)=CC4=C3C=CC=C4C)=O)=O)\C(O)=O)O—
23960-23azi25—
960-22;Threonine
from: 960-22
O[C@H]1[C@@H]([C@@H]2CN2/C1=C(NC([C@H](C(C)C)OC(C3=CC(OC)=CC4=C3C=CC=C4C)=O)=O)\C(NC([C@H](C)O)C([H])=O)=O)O—
24960-24?—
960-23
from: 960-23
CC1=CC=CC2=C1C=C(OC)C=C2C(O[C@@H](C(C)C)C(N/C(C(NC(C([H])=O)[C@@H](O)C)=O)=C3[C@@H](O)[C@H](O)[C@H]4N\3C4)=O)=O—
25960-25Start—
[R]C(C)=O—
26960-26azi34, azi35, azi15—
960-24;960-25
from: 960-24, 960-25
CC1=CC=CC2=C1C=C(OC)C=C2C(O[C@@H]([C@@]3(CO3)C)C(N/C(C(N/C(C(C)=O)=C/O)=O)=C4[C@@H](OC(C)=O)[C@H](O)[C@H]5N\4C5)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture