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BGC0000958Hybrid

Antimycin

Producing organism
Streptomyces sp. S4
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Type I)
Total steps
11
DOI
MIBiG entry
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antimycin
C28H40N2O9548.27 Da

Gene Cluster Map15 genes · 24,626 bp

CCACCALKRKSATTEERAKR5 kb24.6 kb visible · 24,626 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
EREnoylreductase (ER)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
CALCoA-ligase (CAL)

Pathway Graphsteps arranged in biosynthetic order

11 steps · 10 edges
Step 1
Start
Step 2
WP_003946507.1
Step 3
?
Step 4
WP_010639243.1;WP_00394…
Step 5
WP_010639244.1, WP_0039…
Step 6
?
Step 7M1
WP_010639240.1
+Threonine
Step 8M2
WP_010639240.1
+Pyruvate
Step 9M3
WP_010639241.1
+Hexylmalonyl-CoA
Step 10
WP_010639249.1
Step 11
WP_026048085.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1958-1Start—
N[C@H](C(O)=O)CC1=CNC2=C1C=CC=C2—
2958-2WP_003946507.1—
958-1
from: 958-1
O=C(C[C@H](N)C(O)=O)C1=C(NC=O)C=CC=C1—
3958-3?—
958-2
from: 958-2
NC1=C(C(O)=O)C=CC=C1—
4958-4WP_010639243.1;WP_003946500.1—
958-3
from: 958-3
NC1=C(C(O)=O)C=CC=C1—
5958-5WP_010639244.1, WP_003946502.1, WP_010639245.1, WP_003946504.1, WP_010639247.1, WP_010639251.1—
958-4
from: 958-4
NC1=CC=CC(O2)C12C(O)=O—
6958-6?—
958-5
from: 958-5
OC1=C(NC=O)C=CC=C1C(O)=O—
7958-7WP_010639240.1M1
958-6;Threonine
from: 958-6
OC1=C(NC=O)C=CC=C1C(N[C@@H]([C@H](O)C)C(O)=O)=O—
8958-8WP_010639240.1M2
958-7;Pyruvate
from: 958-7
OC1=C(NC=O)C=CC=C1C(N[C@@H]([C@H](O)C)C(O[C@@H](C)C(O)=O)=O)=O—
9958-9WP_010639241.1M3
958-8;Hexylmalonyl-CoA
from: 958-8
OC1=C(NC=O)C=CC=C1C(N[C@@H]([C@H](O)C)C(O[C@@H](C)C([C@@H](CCCCCC)C(O)=O)=O)=O)=O—
10958-10WP_010639249.1—
958-9
from: 958-9
O=CNC1=C(O)C(C(N[C@@H]([C@@H](C)OC2=O)C(O[C@@H](C)[C@@H](O)[C@H]2CCCCCC)=O)=O)=CC=C1—
11958WP_026048085.1—
958-10
from: 958-10
O=CNC1=C(O)C(C(N[C@@H]([C@@H](C)OC2=O)C(O[C@@H](C)[C@@H](OC(CC(C)C)=O)[C@H]2CCCCCC)=O)=O)=CC=C1—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture