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BGC0000954Hybrid

Ajudazol A

Producing organism
Chondromyces crocatus
Taxonomy
Bacteria›Myxococcota›Polyangia›Polyangiales›Polyangiaceae›Chondromyces
Biosynthetic class
NRPS (Type I);PKS (Type I)
Total steps
17
DOI
MIBiG entry
View on MIBiG ↗
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ajudazol A
C34H42N2O7590.30 Da

Gene Cluster Map13 genes · 83,663 bp

KSKSKSKSAKSKSKSKSKSKSAKS20 kb83.7 kb visible · 83,663 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
CyHeterocyclization (Cy)
DH2Dehydratase (DH2)
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

17 steps · 16 edges
Step 1Load
ajuK
+Malonyl-CoA
Step 2M1
ajuK
+Malonyl-CoA
Step 3M2
ajuL
+Glycine
Step 4M3
ajuL
+Malonyl-CoA
Step 5M4
ajuA, ?
+Malonyl-CoA
Step 6M5
ajuB
+Malonyl-CoA
Step 7M6
ajuB
+Malonyl-CoA
Step 8M7
ajuC
+Methylmalonyl-CoA
Step 9M8
ajuD
+Cysteine
Step 10M9
ajuE
+Methylmalonyl-CoA
Step 11M10
ajuF
+Malonyl-CoA
Step 12M11
ajuG
+Malonyl-CoA
Step 13M12
ajuG
+Methylmalonyl-CoA
Step 14M13
ajuH
+Malonyl-CoA
Step 14TE
ajuH
Step 15
ajuI/ajuJ
Step 16
ajuI/ajuJ
+954(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1954-1ajuKLoading
Malonyl-CoA
O=C(C)O—
2954-2ajuKM1
954-1;Malonyl-CoA
from: 954-1
O=C(/C=C(C)\OC)O—
3954-3ajuLM2
954-2;Glycine
from: 954-2
CO/C(C)=C\C(N(CC(O)=O)C)=O—
4954-4ajuLM3
954-3;Malonyl-CoA
from: 954-3
CO/C(C)=C\C(N(C[C@@H](O)CC(O)=O)C)=O—
5954-5ajuA, ?M4
954-4;Malonyl-CoA
from: 954-4
CO/C(C)=C\C(N(C/C=C/CCC(O)=O)C)=O—
6954-6ajuBM5
954-5;Malonyl-CoA
from: 954-5
CO/C(C)=C\C(N(C/C=C/CC[C@@H](O)CC(O)=O)C)=O—
7954-7ajuBM6
954-6;Malonyl-CoA
from: 954-6
CO/C(C)=C\C(N(C/C=C/CC/C=C\C=C/C(O)=O)C)=O—
8954-8ajuCM7
954-7;Methylmalonyl-CoA
from: 954-7
CO/C(C)=C\C(N(C/C=C/CC/C=C\C=C/CC(C(O)=O)C)C)=O—
9954-9ajuDM8
954-8;Cysteine
from: 954-8
CO/C(C)=C\C(N(C/C=C/CC/C=C\C=C/CC(C1=NC(C(O)=O)=CO1)C)C)=O—
10954-10ajuEM9
954-9;Methylmalonyl-CoA
from: 954-9
CO/C(C)=C\C(N(C/C=C/CC/C=C\C=C/CC(C1=NC(C[C@H](C)C(O)=O)=CO1)C)C)=O—
11954-11ajuFM10
954-10;Malonyl-CoA
from: 954-10
CO/C(C)=C\C(N(C/C=C/CC/C=C\C=C/CC(C1=NC(C[C@H](C)[C@@H](CC(O)=O)O)=CO1)C)C)=O—
12954-12ajuGM11
954-11;Malonyl-CoA
from: 954-11
CO/C(C)=C\C(N(C/C=C/CC/C=C\C=C/CC(C1=NC(C[C@H](C)[C@@H](CC(CC(O)=O)=O)O)=CO1)C)C)=O—
13954-13ajuGM12
954-12;Methylmalonyl-CoA
from: 954-12
CO/C(C)=C\C(N(C/C=C/CC/C=C\C=C/CC(C1=NC(C[C@H](C)[C@@H](CC(C[C@@H](C(C(O)=O)C)O)=O)O)=CO1)C)C)=O—
14954-14ajuHM13
954-13;Malonyl-CoA
from: 954-13
CO/C(C)=C\C(N(C/C=C/CC/C=C\C=C/CC(C1=NC(C[C@H](C)[C@@H](CC(C/C=C(C(CC(O)=O)=O)/C)=O)O)=CO1)C)C)=O—
14954-15ajuHTE
954-14
from: 954-14
CO/C(C)=C\C(N(C/C=C/CC/C=C\C=C/CC(C1=NC(C[C@H](C)C(OC2=O)=CC(C2=C3O)=CC=C3C)=CO1)C)C)=O—
15954(1)ajuI/ajuJ—
954-15
from: 954-15
CO/C(C)=C\C(N(C/C=C/CC/C=C\C=C/CC(C1=NC(C[C@H](C)[C@H](OC2=O)[C@H](O)C(C2=C3O)=CC=C3C)=CO1)C)C)=O—
16954(2)ajuI/ajuJ—
954(1)
CO/C(C)=C\C(N(C/C=C/CC/C=C\C=C/CC(C1=NC(C[C@H](C)[C@H](OC2=O)[C@H](O)C(C2=C3O)=CC=C3C)=CO1)=C)C)=O—
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