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BGC0000459NRPS

griseoviridin;fijimycin A

Producing organism
Streptomyces griseoviridis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
30
DOI
MIBiG entry
View on MIBiG ↗
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C22H27N3O7S477.16 Da

Gene Cluster Map36 genes · 104,671 bp

20 kb104.7 kb visible · 104,671 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CnCOM N-term
CcCOM C-term
TEThioesterase (TE)
EEpimerization (E)
CyHeterocyclization (Cy)
DH2Dehydratase (DH2)
DHtDehydratase (DHt)
ECHEnoyl-CoA hydratase
MTMethyltransferase
AmTAminotransferase IV
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

30 steps · 28 edges
Step 1Load
AGN74892.1
Trans-AT
Step 12
start
+Lysine
Step 16
start
+?
Step 19
start
+?
Step 2M1
AGN74892.1
Trans-AT
Step 13
AGN74881.1
Step 17
AGN74883.1
Step 20
AGN74875.1
Step 3M2
AGN74892.1
Trans-AT
Step 14
?
Step 18
?
Step 21
AGN74874.1
Step 4M3
AGN74892.1
+Glycine
Step 15
AGN74901.1,AGN74878.1
Step 5M4
AGN74893.1
Trans-AT
Step 22M1
AGN74880.1
Step 6M5
AGN74894.1
Trans-AT
Step 23M2
AGN74876.1
+L-Threonine
Step 7M6
AGN74894.1
Trans-AT
Step 24M3
AGN74876.1
+L-Leucine
Step 8M7
AGN74895.1
+Serine
Step 25M4
AGN74886.1
+4-hydroxy-D-proli…
Step 9M9
AGN74896.1,AGN74898.1
+Cysteine
Step 26M5
AGN74885.1
+sarcosine
Step 10TE
AGN74896.1
Step 27M6
AGN74885.1
Step 11
AGN74891.1
Step 28M7
AGN74885.1
+L-alanine
Step 29M8
AGN74885.1
Step 30TE
AGN74885.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions30 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1459-1AGN74892.1Loading
OC(C)=O{'transAT': ['AGN74897.1', '…
2459-2AGN74892.1M1
459-1
from: 459-1
OC(C[C@H](O)C)=O{'transAT': ['AGN74897.1', '…
3459-3AGN74892.1M2
459-2
from: 459-2
OC(/C=C/C[C@H](O)C)=O{'transAT': ['AGN74897.1', '…
4459-4AGN74892.1M3
459-3;Glycine
from: 459-3
OC(CNC(/C=C/C[C@H](O)C)=O)=O—
5459-5AGN74893.1M4
459-4
from: 459-4
OC(/C=C/C=C/CNC(/C=C/C[C@H](O)C)=O)=O{'transAT': ['AGN74897.1', '…
6459-6AGN74894.1M5
459-5
from: 459-5
O=C(O)C[C@H](O)/C=C/C=C/CNC(/C=C/C[C@H](O)C)=O{'transAT': ['AGN74897.1', '…
7459-7AGN74894.1M6
459-6
from: 459-6
O[C@H](C[C@H](O)/C=C/C=C/CNC(/C=C/C[C@H](O)C)=O)CC(O)=O{'transAT': ['AGN74897.1', '…
8459-8AGN74895.1M7
459-7;Serine
from: 459-7
OC(C1=COC(C[C@@H](C[C@H](O)/C=C/C=C/CNC(/C=C/C[C@H](O)C)=O)O)=N1)=O—
9459-9AGN74896.1,AGN74898.1M9
459-8;Cysteine
from: 459-8
O=C([C@@H](CS)NC(C1=COC(C[C@@H](C[C@H](O)/C=C/C=C/CNC(/C=C/C[C@H](O)C)=O)O)=N1)=O)O—
10459-10AGN74896.1TE
459-9
from: 459-9
O=C(/C=C/C[C@@H](C)OC([C@H](NC1=O)CS)=O)NC/C=C/C=C/[C@@H](O)C[C@@H](O)CC2=NC1=CO2—
11459(1)AGN74891.1—
459-10
from: 459-10
O=C(/C(SC[C@H]1NC2=O)=C/C[C@@H](C)OC1=O)NC/C=C/C=C/[C@@H](O)C[C@@H](O)CC3=NC2=CO3—
12459-11start—
Lysine
N[C@H](C(O)=O)CCCCN—
13459-12AGN74881.1—
459-11
from: 459-11
O=C(C(O)=O)CCCCN—
14459-13?—
459-12
from: 459-12
O=C(O)C1=NCCCC1—
15459-14AGN74901.1,AGN74878.1—
459-13
from: 459-13
O=C(O)C1=NC=CC=C1O—
16459-15start—
?
[R]C(CC1=CC=CC=C1)=O—
17459-16AGN74883.1—
459-15
from: 459-15
OC(C(C1=CC=CC=C1)=O)=O—
18459-17?—
459-16
from: 459-16
OC([C@H](N)C1=CC=CC=C1)=O—
19459-18start—
?
OC(C(CC(C)C)=O)=O—
20459-19AGN74875.1—
459-18
from: 459-18
OC(C([C@@H](C)C(C)C)=O)=O—
21459-20AGN74874.1—
459-19
from: 459-19
OC([C@@H](N)[C@@H](C)C(C)C)=O—
22459-21AGN74880.1M1
459-14
from: 459-14
OC(C1=NC=CC=C1O)=O—
23459-22AGN74876.1M2
459-21;L-Threonine
from: 459-21
OC([C@H]([C@H](O)C)N(C)C(C1=NC=CC=C1O)=O)=O—
24459-23AGN74876.1M3
459-22;L-Leucine
from: 459-22
OC([C@H](NC([C@H]([C@H](O)C)N(C)C(C1=NC=CC=C1O)=O)=O)CC(C)C)=O—
25459-24AGN74886.1M4
459-23;4-hydroxy-D-proline
from: 459-23
OC([C@@H]1N(C[C@H](O)C1)C([C@H](NC([C@H]([C@H](O)C)N(C)C(C2=NC=CC=C2O)=O)=O)CC(C)C)=O)=O—
26459-25AGN74885.1M5
459-24;sarcosine
from: 459-24
O=C(CN(C([C@@H]1N(C[C@H](O)C1)C([C@H](NC([C@H]([C@H](O)C)N(C)C(C2=NC=CC=C2O)=O)=O)CC(C)C)=O)=O)C)O—
27459-26AGN74885.1M6
459-25;459-20
from: 459-25, 459-20
OC([C@H]([C@H](C(C)C)C)N(C)C(CN(C([C@@H]1N(C[C@H](O)C1)C([C@H](NC([C@H]([C@H](O)C)N(C)C(C2=NC=CC=C2O)=O)=O)CC(C)C)=O)=O)C)=O)=O—
28459-27AGN74885.1M7
459-26;L-alanine
from: 459-26
O=C([C@@H](C)NC([C@H]([C@H](C(C)C)C)N(C)C(CN(C([C@@H]1N(C[C@H](O)C1)C([C@H](NC([C@H]([C@H](O)C)N(C)C(C2=NC=CC=C2O)=O)=O)CC(C)C)=O)=O)C)=O)=O)O—
29459-28AGN74885.1M8
459-27;459-17
from: 459-27, 459-17
OC([C@@H](NC([C@@H](C)NC([C@H]([C@H](C(C)C)C)N(C)C(CN(C([C@@H]1N(C[C@H](O)C1)C([C@H](NC([C@H]([C@H](O)C)N(C)C(C2=NC=CC=C2O)=O)=O)CC(C)C)=O)=O)C)=O)=O)=O)C3=CC=CC=C3)=O—
30459(2)AGN74885.1TE
459-28
from: 459-28
OC1=C(C(N[C@H](C(N[C@H](CC(C)C)C(N2[C@H](C[C@@H](O)C2)C(N(C)CC(N(C)[C@H]3[C@@H](C)C(C)C)=O)=O)=O)=O)[C@H](OC([C@@H](N(C)C([C@@H](C)NC3=O)=O)C4=CC=CC=C4)=O)C)=O)N=CC=C1—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture