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BGC0000453NRPS

valinomycin

Producing organism
Streptomyces tsusimaensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
5
DOI
MIBiG entry
View on MIBiG ↗
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valinomycin
C54H90N6O181110.63 Da

Gene Cluster Map18 genes · 39,345 bp

TEACAECCALKRCATE10 kb39.3 kb visible · 39,345 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
EEpimerization (E)
CALCoA-ligase (CAL)

Pathway Graphsteps arranged in biosynthetic order

5 steps · 4 edges
Step 1M1
vlm1
+D-a-hydroxyisoval…
Step 2M2
vlm1
+D-Valine
Step 3M3
vlm2
+L-lactic acid
Step 4M4
vlm2
+L-Valine
Step 5TE
vlm2
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions5 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1453-1vlm1M1
D-a-hydroxyisovaleric acid
CC(C)[C@H](C(O)=O)O—
2453-2vlm1M2
453-1;D-Valine
from: 453-1
CC(C)[C@H](C(N[C@@H](C(C)C)C(O)=O)=O)O—
3453-3vlm2M3
453-2;L-lactic acid
from: 453-2
CC(C)[C@H](C(N[C@@H](C(C)C)C(O[C@@H](C)C(O)=O)=O)=O)O—
4453-4vlm2M4
453-3;L-Valine
from: 453-3
CC(C)[C@H](C(N[C@@H](C(C)C)C(O[C@@H](C)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)O—
5453vlm2TE
453-4;453-4;453-4
from: 453-4, 453-4, 453-4
CC(C)[C@@H](C(N[C@H](C(C)C)C(O[C@H](C)C(N[C@H](C(C)C)C(O[C@H](C(N[C@H](C(C)C)C(O[C@H](C)C(N[C@H](C(C)C)C(O[C@H](C(N[C@H](C(C)C)C(O[C@H](C)C(N[C@@H]1C(C)C)=O)=O)=O)C(C)C)=O)=O)=O)=O)C(C)C)=O)=O)=O)=O)OC1=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture