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BGC0000450NRPS

Triostin A

Producing organism
Streptomyces triostinicus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
13
DOI
MIBiG entry
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triostin A
C50H62N12O12S21086.41 Da

Gene Cluster Map18 genes · 36,746 bp

CAMTCAMTTETEAA5 kb36.7 kb visible · 36,746 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

13 steps · 12 edges
Step 1
start
+L-Tryptophan
Step 2
trsR;trsH
Step 3
trsB
Step 4
trsQ,trsC
Step 5
trsF
Step 6
trsO
Step 7Load
trsP,trsA
Step 8M1
BAH04162.1
+D-Serine
Step 9M2
BAH04162.1
+L-Alanine
Step 10M3
trsI
+N-methyl-L-Cystei…
Step 11M4
trsI
+N-methyl-L-Valine
Step 12TE
trsI
Step 13
trsN
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1450-1start—
L-Tryptophan
N[C@H](C(O)=O)CC1=CNC2=C1C=CC=C2—
2450-2trsR;trsH—
450-1
from: 450-1
N[C@H](C(O)=O)CC1=CNC2=C1C=CC=C2—
3450-3trsB—
450-2
from: 450-2
N[C@H](C(O)=O)[C@@H](O)C1=CNC2=C1C=CC=C2—
4450-4trsQ,trsC—
450-3
from: 450-3
O[C@H]([C@H](N)C(O)=O)C(C1=C(NC([H])=O)C=CC=C1)=O—
5450-5trsF—
450-4
from: 450-4
NC1=CC=CC=C1C([C@@H]([C@H](N)C(O)=O)O)=O—
6450-6trsO—
450-5
from: 450-5
NC1=CC=CC=C1N[C@H](C(O)=O)[C@@H](O)C(O)=O—
7450-7trsP,trsALoading
450-6
from: 450-6
OC(C(C=N1)=NC2=C1C=CC=C2)=O—
8450-8BAH04162.1M1
450-7;D-Serine
from: 450-7
O=C(N[C@H](CO)C(O)=O)C(C=N1)=NC2=C1C=CC=C2—
9450-9BAH04162.1M2
450-8;L-Alanine
from: 450-8
O=C(N[C@H](CO)C(N[C@@H](C)C(O)=O)=O)C(C=N1)=NC2=C1C=CC=C2—
10450-10trsIM3
450-9;N-methyl-L-Cysteine
from: 450-9
O=C(N[C@H](CO)C(N[C@@H](C)C(N(C)[C@@H](CS)C(O)=O)=O)=O)C(C=N1)=NC2=C1C=CC=C2—
11450-11trsIM4
450-10;N-methyl-L-Valine
from: 450-10
O=C(N[C@H](CO)C(N[C@@H](C)C(N(C)[C@@H](CS)C(N(C)[C@@H](C(C)C)C(O)=O)=O)=O)=O)C(C=N1)=NC2=C1C=CC=C2—
12450-12trsITE
450-11;450-11
from: 450-11, 450-11
O=C(N(C)[C@@](C(N(CC(OC[C@@H](NC(C1=CN=C2C(C=CC=C2)=N1)=O)C(N[C@H]3C)=O)=O)C)=O)([H])CS)[C@H](C)NC([C@@H](COC([C@H](C(C)C)N(C([C@@H](N(C)C3=O)CS)=O)C)=O)NC(C4CN=C5C=CC=CC5=N4)=O)=O—
13450trsN—
450-12
from: 450-12
O=C(N(C)C(C(N(CC(OC[C@@H](NC(C1=CN=C2C(C=CC=C2)=N1)=O)C(N[C@H]3C)=O)=O)C)=O)([H])CSSC[C@H](N(C)C3=O)C(N([C@H]4C(C)C)C)=O)[C@H](C)NC([C@@H](COC4=O)NC(C5CN=C6C=CC=CC6=N5)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture