NPdia

BGC0000448NRPS

Tomaymycin

Producing organism: Streptomyces achromogenes
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I)
Total steps: 13
DOI: 10.1128/AEM.02325-08
MIBiG entry: View on MIBiG ↗

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tomaymycin

C₁₆H₂₀N₂O₄304.14 Da

Biosynthetic (core)

Biosynthetic (additional)

Transport

Unknown

Domains

Acyl carrier protein (ACP)

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

Terminal reductase

13 steps · 12 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`448-1`	start	—	L-Tyrosine	`NC(C(O)=O)CC1=CC=C(O)C=C1`	—
2	`448-2`	tomI	—	448-1 from: 448-1	`NC(C(O)=O)CC1=CC(O)=C(O)C=C1`	—
3	`448-3`	tomH	—	448-2 from: 448-2	`O=C(/C=C\C1=CNC(C(O)=O)C1)C(O)=O`	—
4	`448-4`	tomK	—	448-3 from: 448-3	`C=CC1=CNC(C(O)=O)C1`	—
5	`448-5`	tomN	—	448-4 from: 448-4	`C/C=C1C=NC(C(O)=O)C\1`	—
6	`448-6`	tomL	—	448-5 from: 448-5	`C/C=C1CNC(C(O)=O)C\1`	—
7	`448-7`	Start	—	Chorismate	`OC(C1=C[C@@H]([C@@H](O)C=C1)OC(C(O)=O)=C)=O`	—
8	`448-8`	tomD,tomP	—	448-7 from: 448-7	`NC1=C(C(O)=O)C=CC=C1`	—
9	`448-9`	tomO	—	448-8 from: 448-8	`NC1=C(C(O)=O)C=C(O)C=C1`	—
10	`448-10`	tomE,tomF	—	448-9 from: 448-9	`NC1=C(C(O)=O)C=C(O)C(O)=C1`	—
11	`448-11(1)`	tomG	—	448-10 from: 448-10	`NC1=C(C(O)=O)C=C(OC)C(O)=C1`	—
12	`448-11(2)`	tomA,tomB	—	448-10;448-6 from: 448-10, 448-6	`OC1=CC(C(N(C/C(C2)=C/C)[C@]2([H])C=N3)=O)=C3C=C1O`	—
13	`448`	(tomA,tomB)/tomG	—	(448-11(1);448-6)/448-11(2) from: 448-6)/448-11(2)	`OC1=CC2=C(C(N(C/C(C3)=C/C)[C@]3([H])C=N2)=O)C=C1OC`	—

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