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BGC0000444NRPS

Thaxtomin A

Producing organism
Streptomyces turgidiscabies Car8
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
6
DOI
MIBiG entry
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thaxtomin A
C22H22N4O6438.15 Da

Gene Cluster Map11 genes · 20,623 bp

AMTCAMTC5 kb20.6 kb visible · 20,623 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

6 steps · 5 edges
Step 1
start
+L-Tryptophan
Step 2
start
+L-Arginine
Step 3
stPAI021
Step 5
stPAI029,stPAI030
+L-Phenylalanine
Step 4
stPAI022
Step 6
stPAI031
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions6 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1444-1start—
L-Tryptophan
N[C@H](C(O)=O)CC1=CNC2=C1C=CC=C2—
2444-2start—
L-Arginine
NC(CCCNC(N)=N)C(O)=O—
3444-3stPAI021—
444-2
from: 444-2
[N]=O—
4444-4stPAI022—
444-1;444-3
from: 444-1, 444-3
N[C@H](C(O)=O)CC1=CNC2=C1C([N+]([O-])=O)=CC=C2—
5444-5stPAI029,stPAI030—
444-2;L-Phenylalanine
from: 444-2
O=C([C@@](CC1=CC=CC=C1)([H])N(C2=O)C)N([C@@]2([H])CC3=CNC4=C3C([N+]([O-])=O)=CC=C4)C—
6444stPAI031—
444-3
from: 444-3
O=C([C@@](CC1=CC(O)=CC=C1)(O)N(C2=O)C)N([C@@]2([H])CC3=CNC4=C3C([N+]([O-])=O)=CC=C4)C—
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