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BGC0000439NRPS

Taromycin A

Producing organism
Saccharomonospora piscinae
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Saccharomonospora
Biosynthetic class
NRPS (Type I)
Total steps
15
DOI
MIBiG entry
View on MIBiG ↗
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taromycin A
C70H91Cl2N17O251639.57 Da

Gene Cluster Map30 genes · 76,640 bp

CALAAAAAAAAAAAAA20 kb76.6 kb visible · 76,640 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
EREnoylreductase (ER)
ACPAcyl carrier protein (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
FkFkbH-like
ECHEnoyl-CoA hydratase
CALCoA-ligase (CAL)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

15 steps · 14 edges
Step 1
start
+2,4-Octadienoic a…
Step 2M1
AHH53506.1,?
+Tryptophan
Step 3M2
AHH53506.1
+Aspartic acid
Step 4M3
AHH53506.1
+Aspartic acid
Step 5M4
AHH53506.1
+Threonine
Step 6M5
AHH53506.1
+Glycine
Step 7M6
AHH53507.1
+Ornithine
Step 8M7
AHH53507.1
+Aspartic acid
Step 9M8
AHH53507.1
+Alanine
Step 10M9
AHH53507.1
+Aspartic acid
Step 11M10
AHH53507.1
+Glycine
Step 12M11
AHH53507.1
+Alanine
Step 13M12
AHH53508.1
+Glutamic acid
Step 14M13
AHH53508.1,?
+Kynurenic acid
Step 15TE
AHH53508.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions15 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1439-1start—
2,4-Octadienoic acid
O=C(/C=C/C=C/CCC)O—
2439-2AHH53506.1,?M1
439-1;Tryptophan
from: 439-1
O=C(/C=C/C=C/CCC)N[C@@H](CC1=CNC2=C1C=CC(Cl)=C2)C(O)=O—
3439-3AHH53506.1M2
439-2;Aspartic acid
from: 439-2
O=C(/C=C/C=C/CCC)N[C@@H](CC1=CNC2=C1C=CC(Cl)=C2)C(N[C@H](CC(N)=O)C(O)=O)=O—
4439-4AHH53506.1M3
439-3;Aspartic acid
from: 439-3
O=C(/C=C/C=C/CCC)N[C@@H](CC1=CNC2=C1C=CC(Cl)=C2)C(N[C@H](CC(N)=O)C(N[C@@H](CCC(O)=O)C(O)=O)=O)=O—
5439-5AHH53506.1M4
439-4;Threonine
from: 439-4
O=C(/C=C/C=C/CCC)N[C@@H](CC1=CNC2=C1C=CC(Cl)=C2)C(N[C@H](CC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(O)C)C(O)=O)=O)=O)=O—
6439-6AHH53506.1M5
439-5;Glycine
from: 439-5
O=C(/C=C/C=C/CCC)N[C@@H](CC1=CNC2=C1C=CC(Cl)=C2)C(N[C@H](CC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(O)C)C(NCC(O)=O)=O)=O)=O)=O—
7439-7AHH53507.1M6
439-6;Ornithine
from: 439-6
O=C(/C=C/C=C/CCC)N[C@@H](CC1=CNC2=C1C=CC(Cl)=C2)C(N[C@H](CC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(O)C)C(NCC(N[C@H](C(O)=O)CCCN)=O)=O)=O)=O)=O—
8439-8AHH53507.1M7
439-7;Aspartic acid
from: 439-7
O=C(/C=C/C=C/CCC)N[C@@H](CC1=CNC2=C1C=CC(Cl)=C2)C(N[C@H](CC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(O)C)C(NCC(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)CCCN)=O)=O)=O)=O)=O—
9439-9AHH53507.1M8
439-8;Alanine
from: 439-8
O=C(/C=C/C=C/CCC)N[C@@H](CC1=CNC2=C1C=CC(Cl)=C2)C(N[C@H](CC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(O)C)C(NCC(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](C)C(O)=O)=O)=O)CCCN)=O)=O)=O)=O)=O—
10439-10AHH53507.1M9
439-9;Aspartic acid
from: 439-9
O=C(/C=C/C=C/CCC)N[C@@H](CC1=CNC2=C1C=CC(Cl)=C2)C(N[C@H](CC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(O)C)C(NCC(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](C)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)CCCN)=O)=O)=O)=O)=O—
11439-11AHH53507.1M10
439-10;Glycine
from: 439-10
O=C(/C=C/C=C/CCC)N[C@@H](CC1=CNC2=C1C=CC(Cl)=C2)C(N[C@H](CC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(O)C)C(NCC(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](C)C(N[C@@H](CC(O)=O)C(NCC(O)=O)=O)=O)=O)=O)CCCN)=O)=O)=O)=O)=O—
12439-12AHH53507.1M11
439-11;Alanine
from: 439-11
O=C(/C=C/C=C/CCC)N[C@@H](CC1=CNC2=C1C=CC(Cl)=C2)C(N[C@H](CC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(O)C)C(NCC(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](C)C(N[C@@H](CC(O)=O)C(NCC(N[C@H](C)C(O)=O)=O)=O)=O)=O)=O)CCCN)=O)=O)=O)=O)=O—
13439-13AHH53508.1M12
439-12;Glutamic acid
from: 439-12
O=C(/C=C/C=C/CCC)N[C@@H](CC1=CNC2=C1C=CC(Cl)=C2)C(N[C@H](CC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(O)C)C(NCC(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](C)C(N[C@@H](CC(O)=O)C(NCC(N[C@H](C)C(NC(C(O)=O)[C@@H](C)CC(O)=O)=O)=O)=O)=O)=O)=O)CCCN)=O)=O)=O)=O)=O—
14439-14AHH53508.1,?M13
439-13;Kynurenic acid
from: 439-13
O=C(/C=C/C=C/CCC)N[C@@H](CC1=CNC2=C1C=CC(Cl)=C2)C(N[C@H](CC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(O)C)C(NCC(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](C)C(N[C@@H](CC(O)=O)C(NCC(N[C@H](C)C(NC(C(N[C@@H](CC(C3=C(N)C=C(Cl)C=C3)=O)C(O)=O)=O)[C@@H](C)CC(O)=O)=O)=O)=O)=O)=O)=O)CCCN)=O)=O)=O)=O)=O—
15439AHH53508.1TE
439-14
from: 439-14
O=C(/C=C/C=C/CCC)N[C@@H](CC1=CNC2=C1C=CC(Cl)=C2)C(N[C@H](CC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H]3C(NCC(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@H](C)C(N[C@@H](CC(O)=O)C(NCC(N[C@H](C)C(NC(C(N[C@@H](CC(C4=C(N)C=C(Cl)C=C4)=O)C(O[C@@H]3C)=O)=O)[C@@H](C)CC(O)=O)=O)=O)=O)=O)=O)=O)CCCN)=O)=O)=O)=O)=O—
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