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BGC0000434NRPS

SW-163C;UK-63598;SW-163E;SW-163F;SW-163G

Producing organism
Streptomyces sp. SNA15896
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
22
DOI
MIBiG entry
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C52H60N10O14S21112.37 Da

Gene Cluster Map28 genes · 55,697 bp

AmTAmTAACAECACACA10 kb55.7 kb visible · 55,697 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
EEpimerization (E)
MTMethyltransferase
AmTAminotransferase I/II
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

22 steps · 21 edges
Step 1
start
+Tryptophan
Step 11
swb6;?
+Pyridoxal-5-phosp…
Step 2
swb11;swb18
Step 12
?
+L-Valine
Step 3
swb13
Step 13
?,swb7
Step 4
swb14,swb10
Step 14
swb7
Step 5
?
Step 6
swb1
Step 7
swb2
Step 8
swb12;?
Step 9M1
swb16
+L-Serine
Step 10M2
swb16
+L-Alanine
Step 15M3
swb17
+L-Cysteine
Step 16M4
swb17
Step 17TE
swb17
Step 19
swb20
Step 20
swb8
+434(1)
Step 21
swb9
+434(2)
Step 22
swb9
+434(3)
Step 23
swb9
+434(4)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions22 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1434-1start—
Tryptophan
OC([C@@H](N)CC1=CNC2=CC=CC=C21)=O—
2434-2swb11;swb18—
434-1
from: 434-1
OC([C@@H](N)CC1=CNC2=CC=CC=C21)=O—
3434-3swb13—
434-2
from: 434-2
OC([C@@H](N)[C@@H](O)C1=CNC2=CC=CC=C21)=O—
4434-4swb14,swb10—
434-3
from: 434-3
O=C([C@H](O)[C@@H](C(O)=O)N)C1=CC=CC=C1NC=O—
5434-5?—
434-4
from: 434-4
NC1=CC=CC=C1C([C@H](O)[C@@H](C(O)=O)N)=O—
6434-6swb1—
434-5
from: 434-5
O=C(C(O)=C(C(O)=O)N1)C2=C1C=CC=C2—
7434-7swb2—
434-6
from: 434-6
OC(C1=NC2=C(C=C1O)C=CC=C2)=O—
8434-8swb12;?—
434-7
from: 434-7
OC(C1=NC2=C(C=C1O)C=CC=C2)=O—
9434-9swb16M1
434-8;L-Serine
from: 434-8
OC1=CC(C=CC=C2)=C2N=C1C(N[C@H](CO)C(O)=O)=O—
10434-10swb16M2
434-9;L-Alanine
from: 434-9
OC1=CC(C=CC=C2)=C2N=C1C(N[C@H](CO)C(N[C@@H](C)C(O)=O)=O)=O—
11434-11swb6;?—
Pyridoxal-5-phosphate
N=CC1=C(COP([O-])([O-])=O)C=[NH+]C(C)=C1O—
12434-12?—
434-11;L-Valine
from: 434-11
OC1=C(C)[NH+]=CC(COP([O-])([O-])=O)=C1/C=N/C(C(C[H])C)([H])C(O)=O—
13434-13?,swb7—
434-12
from: 434-12
OC1=C(C)[NH+]=CC(COP([O-])([O-])=O)=C1/C=N/[C@@]2([C@@H](C)C2)C(O)=O—
14434-14swb7—
434-13
from: 434-13
C[C@@H]1[C@](N)(C(O)=O)C1—
15434-15swb17M3
434-10;L-Cysteine
from: 434-10
OC1=CC(C=CC=C2)=C2N=C1C(N[C@H](CO)C(N[C@@H](C)C(N(C)C(CS)C(O)=O)=O)=O)=O—
16434-16swb17M4
434-14;434-15
from: 434-14, 434-15
OC1=CC(C=CC=C2)=C2N=C1C(N[C@H](CO)C(N[C@@H](C)C(N(C)C(CS)C(N(C)C3(C[C@@H]3C)C(O)=O)=O)=O)=O)=O—
17434-17swb17TE
434-16;434-16
from: 434-16, 434-16
OC1=CC(C=CC=C2)=C2N=C1C(NC(COC(C3(C[C@@H]3C)N(C)C(C(CS)N(C(C(N4)C)=O)C)=O)=O)C(NC(C(N(C)C(CS)C(N(C5(C[C@@H]5C)C(OCC(NC(C6=NC7=C(C=CC=C7)C=C6O)=O)C4=O)=O)C)=O)=O)C)=O)=O—
19434(1)swb20—
434-17
from: 434-17
OC1=CC(C=CC=C2)=C2N=C1C(NC(COC(C3(C[C@@H]3C)N4C)=O)C(NC(C(N(C)C(CSSCC(N(C(C(N5)C)=O)C)C4=O)C(N(C6(C[C@@H]6C)C(OCC(NC(C7=NC8=C(C=CC=C8)C=C7O)=O)C5=O)=O)C)=O)=O)C)=O)=O—
20434(2)swb8—
434(1)
OC1=CC(C=CC=C2)=C2N=C1C(N[C@H](COC([C@@]3(C[C@@H]3C)N(C)C([C@H](CS4)N(C([C@@H](N5)C)=O)C)=O)=O)C(N[C@H](C(N(C)[C@]([C@@H]4SC)([H])C(N([C@]6(C[C@@H]6C)C(OC[C@@H](NC(C7=NC8=C(C=CC=C8)C=C7O)=O)C5=O)=O)C)=O)=O)C)=O)=O—
21434(3)swb9—
434(2)
OC1=CC(C=CC=C2)=C2N=C1C(N[C@H](COC([C@@]3(C[C@@H]3C)N(C)C([C@H](CS4)N(C([C@@H](N5)C)=O)C)=O)=O)C(N[C@H](C(N(C)[C@]([C@@H]4SCC)([H])C(N([C@]6(C[C@@H]6C)C(OC[C@@H](NC(C7=NC8=C(C=CC=C8)C=C7O)=O)C5=O)=O)C)=O)=O)C)=O)=O—
22434(4)swb9—
434(3)
OC1=CC(C=CC=C2)=C2N=C1C(N[C@H](COC([C@@]3(C[C@@H]3C)N(C)C([C@H](CS4)N(C([C@@H](N5)C)=O)C)=O)=O)C(N[C@H](C(N(C)[C@]([C@@H]4SC(C)C)([H])C(N([C@]6(C[C@@H]6C)C(OC[C@@H](NC(C7=NC8=C(C=CC=C8)C=C7O)=O)C5=O)=O)C)=O)=O)C)=O)=O—
23434(5)swb9—
434(4)
OC1=CC(C=CC=C2)=C2N=C1C(N[C@H](COC([C@@]3(C[C@@H]3C)N(C)C([C@H](CS4)N(C([C@@H](N5)C)=O)C)=O)=O)C(N[C@H](C(N(C)[C@]([C@@H]4SC(CC)C)([H])C(N([C@]6(C[C@@H]6C)C(OC[C@@H](NC(C7=NC8=C(C=CC=C8)C=C7O)=O)C5=O)=O)C)=O)=O)C)=O)=O—
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