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BGC0000432NRPS

streptothricin F;streptothricin E;streptothricin D;streptothricin C

Producing organism
Streptomyces rochei
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces rochei group
Biosynthetic class
NRPS (Type I)
Total steps
12
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map24 genes · 34,051 bp

ANADAAmTEA5 kb34.0 kb visible · 34,051 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Other
Unknown
Domains
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
EEpimerization (E)
AmTAminotransferase I/II
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

12 steps · 14 edges
Step 1
Start
+Arginine
Step 3
Start
+UDP-N-acetyl-D-gl…
Step 7
Start
+L-Lysine
Step 2
?
Step 8
BAL15728.1
Step 4
BAL15716.1, BAL15719.1
Step 5
BAL15730.1
+?
Step 6
BAL15718.1
Step 9M1
BAL15731.1, ?
Step 10M1
BAL15731.1, ?
+432(1)
Step 11M1
BAL15731.1, ?
+432(2)
Step 12M1
BAL15731.1, ?
+432(3)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions12 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1432-1Start—
Arginine
O=C(O)C(CCCNC(N)=N)N—
2432-2?—
432-2
from: 432-2
N=C1N[C@@]([C@H](O)CNC2=O)([H])[C@]2([H])N1—
3432-3Start—
UDP-N-acetyl-D-glucosamine
O[C@@H]1[C@H](O)[C@@H](NC(C)=O)[C@@H]([R])O[C@@H]1CO—
4432-4BAL15716.1, BAL15719.1—
432-2;432-3
from: 432-2, 432-3
O[C@@H]1[C@@H](O)[C@@H](NC(C)=O)[C@H](NC2=N[C@@]3([H])[C@]([C@H](O)CNC3=O)([H])N2)O[C@@H]1CO—
5432-5BAL15730.1—
432-4;?
from: 432-4
O[C@@H]1[C@@H](O)[C@@H](NC(C)=O)[C@H](NC2=N[C@@]3([H])[C@]([C@H](O)CNC3=O)([H])N2)O[C@@H]1COC(N)=O—
6432-6BAL15718.1—
432-5
from: 432-5
O=C(O[C@@H]1[C@@H](O)[C@@H](N)[C@H](/N=C2N[C@@]([C@H](O)CNC3=O)([H])[C@]3([H])N\2)O[C@@H]1CO)N—
7432-7Start—
L-Lysine
O=C(O)[C@H](CCCCN)N—
8432-8BAL15728.1—
432-7
from: 432-7
O=C(O)C[C@@H](N)CCCN—
9432(1)BAL15731.1, ?M1
432-5;432-8
from: 432-5, 432-8
O=C(O[C@@H]1[C@@H](O)[C@@H](NC(C[C@@H](N)CCCN[H])=O)[C@H](/N=C2N[C@@]([C@H](O)CNC3=O)([H])[C@]3([H])N\2)O[C@@H]1CO)N—
10432(2)BAL15731.1, ?M1
432(1);432-8
from: 432-8
O=C(O[C@@H]1[C@@H](O)[C@@H](NC(C[C@@H](N)CCCNCC(C[C@@H](N)CCCN[H])=O)=O)[C@H](/N=C2N[C@@]([C@H](O)CNC3=O)([H])[C@]3([H])N\2)O[C@@H]1CO)N—
11432(3)BAL15731.1, ?M1
432(2);432-8
from: 432-8
O=C(O[C@@H]1[C@@H](O)[C@@H](NC(C[C@@H](N)CCCNCC(C[C@@H](N)CCCNCC(C[C@@H](N)CCCN[H])=O)=O)=O)[C@H](/N=C2N[C@@]([C@H](O)CNC3=O)([H])[C@]3([H])N\2)O[C@@H]1CO)N—
12432(4)BAL15731.1, ?M1
432(3);432-8
from: 432-8
O=C(CNCCC[C@H](N)CC(CNCCC[C@H](N)CC(CNCCC[C@H](N)CC(N[C@@H]1[C@H](O)[C@@H](OC(N)=O)[C@@H](CO)O[C@H]1/N=C2N[C@@]([C@H](O)CNC3=O)([H])[C@]3([H])N\2)=O)=O)=O)C[C@@H](N)CCCN[H]—
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