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BGC0000428NRPS

sibiromycin

Producing organism
Streptosporangium sibiricum
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Streptosporangiales›Streptosporangiaceae›Streptosporangium
Biosynthetic class
NRPS (Type I)
Total steps
26
DOI
MIBiG entry
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sibiromycin
C24H33N3O7475.23 Da

Gene Cluster Map26 genes · 32,713 bp

CATDAAmT5 kb32.7 kb visible · 32,713 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TDTerminal reductase
AmTAminotransferase I/II
AmTAminotransferase V

Pathway Graphsteps arranged in biosynthetic order

26 steps · 25 edges
Step 1
start
+L-Tryptophan
Step 7
start
+L-Tyrosine
Step 17
start
+D-glucose-1-phosp…
Step 2
sibP
Step 8
sibU
Step 18
sibI
Step 3
sibK
Step 9
sibV
Step 19
?
Step 4
sibC
Step 10
sibS
Step 20
sibJ
Step 5
sibQ
Step 11
sibZ
Step 21
sibM
Step 6
sibL
Step 12
sibT
Step 22
sibN
Step 13
sibW
Step 14
sibG
Step 23
sibO
Step 24
sibH
Step 15
sibD,sibE
Step 25
sibH/sibO
Step 16
(sibD,sibE)/sibG
+(428-14(1)
Step 26
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions26 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1428-1start—
L-Tryptophan
NC(C(O)=O)CC1=CNC2=C1C=CC=C2—
2428-2sibP—
428-1
from: 428-1
O=CNC1=C(C(CC(C(O)=O)N)=O)C=CC=C1—
3428-3sibK—
428-2
from: 428-2
NC1=C(C(CC(C(O)=O)N)=O)C=CC=C1—
4428-4sibC—
428-3
from: 428-3
NC1=C(C(CC(C(O)=O)N)=O)C=CC=C1O—
5428-5sibQ—
428-4
from: 428-4
NC1=C(C(O)=O)C=CC=C1O—
6428-6sibL—
428-5
from: 428-5
NC1=C(C(O)=O)C=CC(C)=C1O—
7428-7start—
L-Tyrosine
NC(C(O)=O)CC1=CC=C(O)C=C1—
8428-8sibU—
428-7
from: 428-7
NC(C(O)=O)CC1=CC(O)=C(O)C=C1—
9428-9sibV—
428-8
from: 428-8
O=C(/C=C\C1=CNC(C(O)=O)C1)C(O)=O—
10428-10sibS—
428-9
from: 428-9
C=CC1=CNC(C(O)=O)C1—
11428-11sibZ—
428-10
from: 428-10
CC/C=C1C=NC(C(O)=O)C\1—
12428-12sibT—
428-11
from: 428-11
CC/C=C1CNC(C(O)=O)C\1—
13428-13sibW—
428-12
from: 428-12
C/C=C/C1=CNC(C(O)=O)C1—
14428-14(1)sibG—
428-6
from: 428-6
NC1=C(C(O)=O)C=C(O)C(C)=C1O—
15428-14(2)sibD,sibE—
428-6;428-13
from: 428-6, 428-13
OC1=C(C)C=CC2=C1N=C[C@@]3([H])N(C=C(/C=C/C)C3)C2=O—
16428-15(sibD,sibE)/sibG—
(428-14(1);428-13)/428-14(2)
from: 428-13)/428-14(2)
OC1=C(C)C(O)=CC2=C1N=C[C@@]3([H])N(C=C(/C=C/C)C3)C2=O—
17428-16start—
D-glucose-1-phosphate
O[C@H]1[C@H](O)[C@@H](CO)OC(OP([O-])([O-])=O)[C@@H]1O—
18428-17sibI—
428-16
from: 428-16
O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([R])[C@@H]1O—
19428-18?—
428-17
from: 428-17
C[C@H]1O[C@H]([R])[C@H](O)[C@@H](O)C1=O—
20428-19sibJ—
428-18
from: 428-18
O[C@@H]([C@@H]([R])O[C@H]1C)[C@H](O)C1=O—
21428-20sibM—
428-19
from: 428-19
O[C@@H]([C@@H]([R])O[C@H]1C)[C@@](O)(C)C1=O—
22428-21sibN—
428-20
from: 428-20
O[C@@H]1[C@@](O)(C)[C@@H](NC)[C@H](C)O[C@H]1[R]—
23428-22(1)sibO—
428-21
from: 428-21
O[C@@H]1[C@@](O)(C)[C@@H](N)[C@H](C)O[C@H]1[R]—
24428-22(2)sibH—
428-21
from: 428-21
O[C@@H]1[C@@](O)(C)[C@@H](NC)[C@H](C)O[C@@H]1[R]—
25428-23sibH/sibO—
428-22(1)/422-22(2)
from: 428-22(1)/422-22(2)
O[C@@H]1[C@@](O)(C)[C@@H](N)[C@H](C)O[C@@H]1[R]—
26428?—
428-15;428-23
from: 428-15, 428-23
OC1=C(C)C(O[C@H]2[C@H](O)[C@@](O)(C)[C@@H](NC)[C@H](C)O2)=CC3=C1N=C[C@@]4([H])N(C=C(/C=C/C)C4)C3=O—
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