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BGC0000422NRPS

saframycin A;saframycin B

Producing organism
Streptomyces lavendulae
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
14
DOI
MIBiG entry
View on MIBiG ↗
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C29H30N4O8562.21 Da

Gene Cluster Map47 genes · 62,804 bp

CALCAAA10 kb62.8 kb visible · 62,804 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
MTMethyltransferase
TDTerminal reductase
CALCoA-ligase (CAL)

Pathway Graphsteps arranged in biosynthetic order

14 steps · 12 edges
Step 1
sfmO5
+Tyrosine
Step 4Load
sfmA
+Alanine
Step 2
sfmM2,sfmM3
Step 5M1
sfmB
+Glycine
Step 3
sfmD
Step 6M2
sfmC
Iterative
Step 8MRE
sfmC
Step 9
sfmCy1,sfmCy2
Step 10
sfmM1,sfmO2
Step 11
sfmO4
Step 12
sfmO1
Step 13
?
Step 14
?
+KCN
Step 15
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions14 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1422-1sfmO5—
Tyrosine
OC1=CC=C(CC(N)C(O)=O)C=C1—
2422-2sfmM2,sfmM3—
422-1
from: 422-1
NC(C(O)=O)CC1=CC(C)=C(OC)C=C1—
3422-3sfmD—
422-2
from: 422-2
NC(C(O)=O)CC1=CC(C)=C(OC)C(O)=C1—
4422-4sfmALoading
Alanine
O=C(C(N)C)O—
5422-5sfmBM1
422-4;Glycine
from: 422-4
O=C(C(N)C)NCC(O)=O—
6422-6sfmCM2
422-5
from: 422-5
O=C(C(N)C)NCC(NC(CC1=CC(O)=C(OC)C(C)=C1)C(NC(CC2=CC(O)=C(OC)C(C)=C2)C(O)=O)=O)=O{'Iteration': [([None], '422…
8422-7sfmCMRE
422-6
from: 422-6
OC(C(CC1=CC(O)=C(OC)C(C)=C1)NC2=O)N(C2CC3=CC(O)=C(OC)C(C)=C3)C(CNC(C(C)N)=O)=O—
9422-8sfmCy1,sfmCy2—
422-7
from: 422-7
OC(C1NC2C3=C(C=C(C)C(OC)=C3O)C1)N(C2CC4=CC(O)=C(OC)C(C)=C4)C(CNC(C(C)N)=O)=O—
10422-9sfmM1,sfmO2—
422-8
from: 422-8
OC(C1N(C)C2C3=C(C=C(C)C(OC)=C3O)C1)N(C2C4)C(C5=C4C(C(C)=C(OC)C5=O)=O)CNC(C(C)N)=O—
11422-10sfmO4—
422-9
from: 422-9
OC(C1N(C)C2C3=C(C(O)=C(C)C(OC)=C3O)C1)N(C2C4)C(C5=C4C(C(C)=C(OC)C5=O)=O)CNC(C(C)N)=O—
12422-11sfmO1—
422-10
from: 422-10
OC(C1N(C)C2C3=C(C(C(C)=C(OC)C3=O)=O)C1)N(C2C4)C(C5=C4C(C(C)=C(OC)C5=O)=O)CNC(C(C)N)=O—
13422-12?—
422-11
from: 422-11
OC(C1N(C)C2C3=C(C(C(C)=C(OC)C3=O)=O)C1)N(C2C4)C(C5=C4C(C(C)=C(OC)C5=O)=O)CNC(C(C)=O)=O—
14422(1)?—
422-12;KCN
from: 422-12
O=C(C)C(NCC1N(C(C#N)C2N(C)C3C4=C(C(C(C)=C(OC)C4=O)=O)C2)C3CC5=C1C(C(OC)=C(C)C5=O)=O)=O—
15422(2)?—
422-12/422(1)
from: 422-12/422(1)
O=C(C)C(NCC1N(CC2N(C)C3C4=C(C(C(C)=C(OC)C4=O)=O)C2)C3CC5=C1C(C(OC)=C(C)C5=O)=O)=O—
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