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BGC0000415NRPS

quinomycin

Producing organism
Streptomyces griseovariabilis subsp. bandungensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
13
DOI
MIBiG entry
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quinomycin
C51H64N12O12S21100.42 Da

Gene Cluster Map17 genes · 36,568 bp

CAMTCAMTTECAECATEAA5 kb36.6 kb visible · 36,568 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
EEpimerization (E)
MTMethyltransferase
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

13 steps · 12 edges
Step 1
start
+L-Tryptophan
Step 2
qui18;qui5
Step 3
qui15
Step 4
qui14
Step 5
qui17
Step 6
qui3,qui12,qui13
Step 7M1
qui7,?
+D-Serine
Step 8M2
qui7
+L-Alanine
Step 9M3
qui6
+N-methyl-L-Cystei…
Step 10M4
qui6
+N-methyl-L-Valine
Step 11TE
qui6
Step 12
qui11
Step 13
qui8
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1415-1start—
L-Tryptophan
N[C@H](C(O)=O)CC1=CNC2=C1C=CC=C2—
2415-2qui18;qui5—
415-1
from: 415-1
N[C@H](C(O)=O)CC1=CNC2=C1C=CC=C2—
3415-3qui15—
415-2
from: 415-2
N[C@H](C(O)=O)[C@@H](O)C1=CNC2=C1C=CC=C2—
4415-4qui14—
415-3
from: 415-3
N[C@H](C(O)=O)[C@@H](O)C1=CNC2=C1C=CC=C2—
5415-5qui17—
415-4
from: 415-4
O=C([H])NC1=CC=CC=C1C([C@@H]([C@@H](C(O)=O)N)O)=O—
6415-6qui3,qui12,qui13—
415-5
from: 415-5
OC(C(C=N1)=NC2=C1C=CC=C2)=O—
7415-7qui7,?M1
415-6;D-Serine
from: 415-6
O=C(N[C@H](CO)C(O)=O)C(C=N1)=NC2=C1C=CC=C2—
8415-8qui7M2
415-7;L-Alanine
from: 415-7
O=C(N[C@H](CO)C(N[C@@H](C)C(O)=O)=O)C(C=N1)=NC2=C1C=CC=C2—
9415-9qui6M3
415-8;N-methyl-L-Cysteine
from: 415-8
O=C(N[C@H](CO)C(N[C@@H](C)C(N(C)[C@@H](CS)C(O)=O)=O)=O)C(C=N1)=NC2=C1C=CC=C2—
10415-10qui6M4
415-9;N-methyl-L-Valine
from: 415-9
O=C(N[C@H](CO)C(N[C@@H](C)C(N(C)[C@@H](CS)C(N(C)[C@@H](C(C)C)C(O)=O)=O)=O)=O)C(C=N1)=NC2=C1C=CC=C2—
11415-11qui6TE
415-10
from: 415-10
O=C(N(C)[C@@](C(N(CC(OC[C@@H](NC(C1=CN=C2C(C=CC=C2)=N1)=O)C(N[C@H]3C)=O)=O)C)=O)([H])CS)[C@H](C)NC([C@@H](COC([C@H](C(C)C)N(C([C@@H](N(C)C3=O)CS)=O)C)=O)NC(C4CN=C5C=CC=CC5=N4)=O)=O—
12415-12qui11—
415-11
from: 415-11
O=C(N(C)C(C(N(CC(OC[C@@H](NC(C1=CN=C2C(C=CC=C2)=N1)=O)C(N[C@H]3C)=O)=O)C)=O)([H])CSSC[C@H](N(C)C3=O)C(N([C@H]4C(C)C)C)=O)[C@H](C)NC([C@@H](COC4=O)NC(C5CN=C6C=CC=CC6=N5)=O)=O—
13415qui8—
415-12
from: 415-12
O=C(N(C)[C@@](C(N(CC(OC[C@@H](NC(C1=CN=C2C(C=CC=C2)=N1)=O)C(N[C@H]3C)=O)=O)C)=O)([H])[C@H](SC)SC[C@H](N(C)C3=O)C(N([C@H]4C(C)C)C)=O)[C@H](C)NC([C@@H](COC4=O)NC(C5CN=C6C=CC=CC6=N5)=O)=O—
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