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BGC0000409NRPS

porothramycin A

Producing organism
Streptomyces albus subsp. albus
Taxonomy
BacteriaActinomycetotaActinomycetesKitasatosporalesStreptomycetaceaeStreptomyces
Biosynthetic class
NRPS (Type I)
Total steps
17
DOI
MIBiG entry
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porothramycin A
C18H21N3O4343.15 Da

Gene Cluster Map34 genes · 54,514 bp

ACA10 kb54.5 kb visible · 54,514 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TDTerminal reductase
AmTAminotransferase V

Pathway Graphsteps arranged in biosynthetic order

17 steps · 16 edges
Step 1
start
+Tryptophan
Step 7
start
+Tyrosine
Step 2
?
Step 8
AEA29637.2
Step 3
AEA29642.1
Step 9
AEA29636.2
Step 4
AEA29644.1
Step 10
AEA29633.1,AEA29634.1,A…
Step 5
AEA29640.1
Step 11
AEA29635.2
Step 6
AEA29649.1
Step 12
AEA29632.1
Step 13
AEA29646.2/AEA29650.1,A…
Step 14
AEA29646.2/AEA29650.1,A…
Step 15
AEA29631.1
Step 16
AEA29648.1
Step 17
?
Starting stepIntermediateFinal productModuleLoadingTENo modulePKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1409-1start
Tryptophan
NC(C(O)=O)CC1=CNC2=CC=CC=C21
2409-2?
409-1
from: 409-1
NC(C(O)=O)CC(C1=CC=CC=C1NC=O)=O
3409-3AEA29642.1
409-2
from: 409-2
NC1=CC=CC=C1C(CC(C(O)=O)N)=O
4409-4AEA29644.1
409-3
from: 409-3
NC1=C(O)C=CC=C1C(CC(C(O)=O)N)=O
5409-5AEA29640.1
409-4
from: 409-4
NC1=C(O)C=CC=C1C(O)=O
6409-6AEA29649.1
409-5
from: 409-5
NC1=C(OC)C=CC=C1C(O)=O
7409-7start
Tyrosine
NC(C(O)=O)CC1=CC=C(O)C=C1
8409-8AEA29637.2
409-7
from: 409-7
NC(C(O)=O)CC1=CC=C(O)C(O)=C1
9409-9AEA29636.2
409-8
from: 409-8
O=C(/C=C\C1=CNC(C(O)=O)C1)C(O)=O
10409-10AEA29633.1,AEA29634.1,AEA29638.1,AEA29639.2
409-9
from: 409-9
CC/C=C1CNC(C(O)=O)C\1
11409-11AEA29635.2
409-10
from: 409-10
C/C=C/C1=CNC(C(O)=O)C1
12409-12AEA29632.1
409-11
from: 409-11
OC/C=C/C1=CNC(C(O)=O)C1
13409-13AEA29646.2/AEA29650.1,AEA29624.1
409-12
from: 409-12
O=C/C=C/C1=CNC(C(O)=O)C1
14409-14AEA29646.2/AEA29650.1,AEA29624.1
409-13
from: 409-13
O=C(O)/C=C/C1=CNC(C(O)=O)C1
15409-15AEA29631.1
409-14
from: 409-14
O=C(N)/C=C/C1=CNC(C(O)=O)C1
16409-16AEA29648.1
409-15
from: 409-15
O=C(N(C)C)/C=C/C1=CNC(C(O)=O)C1
17409?
409-6;409-16
from: 409-6, 409-16
COC1=C(N=C[C@]2([H])CC(/C=C/C(N(C)C)=O)=CN23)C(C3=O)=CC=C1
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