NPdia

BGC0000395NRPS

norcardicin A

Producing organism: Nocardia uniformis subsp. tsuyamanensis
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Mycobacteriales›Nocardiaceae›Nocardia
Biosynthetic class: NRPS (Type I)
Total steps: 8
DOI: 10.1038/s41467-019-11740-6
MIBiG entry: View on MIBiG ↗

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nocardicin A

C₂₃H₂₄N₄O₉500.15 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Transport

Unknown

Domains

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

Thioesterase (TE)

Epimerization (E)

Aminotransferase I/II

8 steps · 7 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`395-1`	nocA	M1	hydroxyphenylglycine	`OC([C@@H](N)C1=CC=C(O)C=C1)=O`	—
2	`395-2`	nocA	M2	395-1;Arginine from: 395-1	`OC([C@@H](NC([C@@H](N)C1=CC=C(O)C=C1)=O)CCCNC(N)=[NH2+])=O`	—
3	`395-3`	nocA	M3	395-2;hydroxyphenylglycine from: 395-2	`OC([C@@H](C1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](N)C2=CC=C(O)C=C2)=O)CCCNC(N)=[NH2+])=O)=O`	—
4	`395-4`	nocB	M4	395-3;Serine from: 395-3	`O=C([C@@H](C1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](N)C2=CC=C(O)C=C2)=O)CCCNC(N)=[NH2+])=O)N[C@@H](CO)C(O)=O`	—
5	`395-5`	nocB	M5	395-4;hydroxyphenylglycine from: 395-4	`OC([C@H](C1=CC=C(O)C=C1)N2C[C@@](NC([C@@H](C3=CC=C(O)C=C3)NC([C@@H](NC([C@@H](N)C4=CC=C(O)C=C4)=O)CCCNC(N)=[NH2+])=O)=O)([H])C2=O)=O`	—
6	`395-6`	nocB	TE	395-5 from: 395-5	`O=C1[C@](NC([C@H](NC([C@@H](NC([C@@H](N)C2=CC=C(O)C=C2)=O)CCCNC(N)=[NH2+])=O)C3=CC=C(O)C=C3)=O)([H])CN1[C@H](C(O)=O)C4=CC=C(O)C=C4`	—
7	`395-7`	?	—	395-6 from: 395-6	`O=C([C@H](N)CCOC(C=C1)=CC=C1[C@@H](N)C(N[C@]2([H])C(N(C2)[C@H](C(O)=O)C3=CC=C(O)C=C3)=O)=O)O`	—
8	`395`	?	—	395-7 from: 395-7	`O=C([C@H](N)CCOC(C=C1)=CC=C1/C(C(N[C@]2([H])C(N(C2)[C@H](C(O)=O)C3=CC=C(O)C=C3)=O)=O)=N/O)O`	—

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