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BGC0000394NRPS

naphthyridinomycin

Producing organism
Streptomyces lusitanus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
16
DOI
MIBiG entry
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naphthyridinomycin
C21H27N3O6417.19 Da

Gene Cluster Map28 genes · 51,977 bp

ACACCALCACACA10 kb52.0 kb visible · 51,977 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
MTMethyltransferase
TDTerminal reductase
ACPSACP synthase
CALCoA-ligase (CAL)
TauDTauD oxygenase

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1
start
+Tyrosine
Step 6Load
AGD80622.1
+Fatty acid
Step 2
AGD80625.1
Step 7M1
AGD80623.1
+Alanine
Step 3
AGD80624.1
Step 8M2
AGD80623.1
+Alanine
Step 4
AGD80626.1
Step 9M3
AGD80623.1
+Alanine
Step 5
AGD80617.1
Step 10M4
AGD80612.1;AGD80610.1;A…
+Hydroxymalonyl-CoA
Step 11M5
AGD80620.1
Step 12M6
AGD80618.1
+Glutamic semialde…
Step 13
AGD80618.1
Step 14
?
+Serine
Step 15
AGD80608.1,AGD80629.1
Step 16
AGD80614.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1394-1start—
Tyrosine
OC1=CC=C(C[C@H](N)C(O)=O)C=C1—
2394-2AGD80625.1—
394-1
from: 394-1
OC1=C(C)C=C(C[C@H](N)C(O)=O)C=C1—
3394-3AGD80624.1—
394-2
from: 394-2
OC1=C(C)C=C(C[C@H](N)C(O)=O)C=C1O—
4394-4AGD80626.1—
394-3
from: 394-3
OC([C@@H](N)CC1=CC(C)=C(OC)C(O)=C1)=O—
5394-5AGD80617.1—
394-4
from: 394-4
OC([C@@H](N)C(O)C1=CC(C)=C(OC)C(O)=C1)=O—
6394-6AGD80622.1Loading
Fatty acid
O=C(O)CCCCCCCCCCCCC—
7394-7AGD80623.1M1
394-6;Alanine
from: 394-6
O=C(N[C@@H](C)C(O)=O)CCCCCCCCCCCCC—
8394-8AGD80623.1M2
394-7;Alanine
from: 394-7
O=C(N[C@@H](C)C(N[C@@H](C)C(O)=O)=O)CCCCCCCCCCCCC—
9394-9AGD80623.1M3
394-8;Alanine
from: 394-8
O=C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(O)=O)=O)=O)CCCCCCCCCCCCC—
10394-10AGD80612.1;AGD80610.1;AGD80616.1M4
394-9;Hydroxymalonyl-CoA
from: 394-9
O=C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(OCC(O)=O)=O)=O)=O)CCCCCCCCCCCCC—
11394-11AGD80620.1M5
394-10;394-5
from: 394-10, 394-5
O=C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(OCC1C2=C(C(O)C(N1)C(O)=O)C=C(C)C(OC)=C2O)=O)=O)=O)CCCCCCCCCCCCC—
12394-12AGD80618.1M6
394-11;Glutamic semialdehyde
from: 394-11
O=C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(OCC1C2=C(C(O)[C@](N1)([H])[C@@]3([H])N[C@@](C=O)([H])C[C@H]3C=O)C=C(C)C(OC)=C2O)=O)=O)=O)CCCCCCCCCCCCC—
13394-13AGD80618.1—
394-12
from: 394-12
O=C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(OCC1C2=C(C(O)[C@](N1)([H])[C@@]3([H])N[C@@](C=O)([H])C[C@H]3C=O)C=C(C)C(OC)=C2O)=O)=O)=O)CCCCCCCCCCCCC—
14394-14?—
394-13;Serine
from: 394-13
O=C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(OC[C@]1([H])N([C@@H](O)[C@H]2N[C@]3([H])[C@H](C2)[C@@H]4N5CCO4)[C@@]3([H])[C@@]5([H])C6=C1C(O)=C(OC)C(C)=C6)=O)=O)=O)CCCCCCCCCCCCC—
15394-15AGD80608.1,AGD80629.1—
394-14
from: 394-14
O=C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(OC[C@]1([H])N([C@@H](O)[C@H]2N([C@]3([H])[C@H](C2)[C@@H]4N5CCO4)C)[C@@]3([H])[C@@]5([H])C(C(C(C)=C6OC)=O)=C1C6=O)=O)=O)=O)CCCCCCCCCCCCC—
16394AGD80614.1—
394-15
from: 394-15
OC[C@]1([H])N([C@@H](O)[C@H]2N([C@]3([H])[C@H](C2)[C@@H]4N5CCO4)C)[C@@]3([H])[C@@]5([H])C(C(C(C)=C6OC)=O)=C1C6=O—
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