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BGC0000391NRPS

methylpendolmycin;pendolmycin

Producing organism
Marinactinospora thermotolerans
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Streptosporangiales›Nocardiopsaceae›Marinactinospora
Biosynthetic class
NRPS (Type I)
Total steps
9
DOI
MIBiG entry
View on MIBiG ↗
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C23H33N3O2383.26 Da

Gene Cluster Map7 genes · 14,231 bp

CAMTPCPCATDKR2 kb14.2 kb visible · 14,231 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
MTMethyltransferase
TDTerminal reductase

Pathway Graphsteps arranged in biosynthetic order

9 steps · 10 edges
Step 1Load
AFO85453.1
+Valine/Isoleucine
Step 5
Start
+Isopentenyl dipho…
Step 2M1
AFO85453.1
Step 6
AFO85457.1
Step 3M1
AFO85453.1
Step 4
AFO85454.1
Step 7
AFO85455.1
Step 8
AFO85455.1
Step 9
AFO85455.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions9 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1391-1AFO85453.1Loading
Valine/Isoleucine
O=C(O)[C@@H](NC)[C@H](C[R])C—
2391-2AFO85453.1M1
391-1
from: 391-1
O=C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O)[C@@H](NC)[C@H](C[R])C—
3391-3AFO85453.1M1
391-2
from: 391-2
O=C([C@H]([C@H](C[R])C)NC)N[C@H](CO)CC1=CNC2=CC=CC=C21—
4391-4AFO85454.1—
391-3
from: 391-3
O=C([C@H]([C@H](C[R])C)N1C)N[C@H](CO)CC2=CNC3=CC=CC1=C32—
5391-5Start—
Isopentenyl diphosphate
C=C(C)CCO[P][P]—
6391-6AFO85457.1—
391-5
from: 391-5
C/C(C)=C/CO[P][P]—
7391-7AFO85455.1—
391-4;391-6
from: 391-4, 391-6
O=C([C@H]([C@H](C[R])C)N1C)N[C@H](CO)CC2=CNC3=C(C(C=C)(C)C)C=CC1=C32—
8391(1)AFO85455.1—
391-4;391-6
from: 391-4, 391-6
O=C([C@H](C(C)C)N1C)N[C@H](CO)CC2=CNC3=C(C(C=C)(C)C)C=CC1=C32—
9391(2)AFO85455.1—
391-4;391-6
from: 391-4, 391-6
O=C([C@H]([C@H](CC)C)N1C)N[C@H](CO)CC2=CNC3=C(C(C=C)(C)C)C=CC1=C32—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture