NPdia

BGC0000382NRPS

lipstatin

Producing organism: Streptomyces toxytricini
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I)
Total steps: 11
DOI: 10.1128/AEM.01765-14
MIBiG entry: View on MIBiG ↗

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lipstatin

C₂₉H₄₉NO₅491.36 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Unknown

Domains

Adenylation (A)

Acyl carrier (ACP)

Thioesterase (TE)

NAD-binding

11 steps · 10 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`382-1`	Start	—	Octanoic acid	`CCCCCCCC(O)=O`	—
2	`382-2`	lstC	—	382-1 from: 382-1	`CCCCCCCC([R])=O`	—
3	`382-3`	?	—	382-2 from: 382-2	`CCCCCCC(C([R])=O)C(O)=O`	—
4	`382-4`	?	—	382-3 from: 382-3	`CCCCCCC(C(O)=O)C(O)=O`	—
5	`382-5`	Start	—	Linolyl-CoA	`CCCCC/C=C\C/C=C\CCCCCCCC([R])=O`	—
6	`382-6`	?	—	382-5 from: 382-5	`CCCCC/C=C\C/C=C\C[C@H](O)CC(O)=O`	—
7	`382-7`	lstA,lstB	—	382-4;382-6 from: 382-4, 382-6	`CCCCC/C=C\C/C=C\C[C@H](O)CC(C(CCCCCC)C(O)=O)=O`	—
8	`382-8`	Start	—	leucine	`N[C@@H](CC(C)C)C(O)=O`	—
9	`382-9`	lstE,lstF	—	382-8 from: 382-8	`OC([C@H](CC(C)C)NC=O)=O`	—
10	`382-10`	lstE,lstF	M1	382-7;382-9 from: 382-7, 382-9	`CCCCC/C=C\C/C=C\C[C@H](OC([C@H](CC(C)C)NC=O)=O)CC(C(CCCCCC)C(O)=O)=O`	—
11	`382`	lstD	—	382-10 from: 382-10	`CCCCC/C=C\C/C=C\C[C@H](OC([C@H](CC(C)C)NC=O)=O)C[C@@H](C1CCCCCC)OC1=O`	—

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