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BGC0000379NRPS

glycinocin A

Producing organism
Streptomyces viridochromogenes
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
13
DOI
MIBiG entry
View on MIBiG ↗
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glycinocin A
C57H90N12O191246.64 Da

Gene Cluster Map43 genes · 88,912 bp

CAL20 kb88.9 kb visible · 88,912 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
CALCoA-ligase (CAL)
TauDTauD oxygenase
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

13 steps · 12 edges
Step 1
start
+?
Step 2M1
lpmA
+Aspartic acid
Step 3M2
lpmB
+diaminopropionic …
Step 4M3
lpmB
+pipecolic acid
Step 5M4
lpmC
+Glycine
Step 6M5
lpmC
+Aspartic acid
Step 7M6
lpmC
+Glycine
Step 8M7
lpmC
Step 9M8
lpmC
+Glycine
Step 10M9
lpmC
+Threonine
Step 11M10
lpmD
+Isoleucine
Step 12M11
lpmD
+Proline
Step 13TE
lpmD
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1379-1start—
?
OC(/C=C/CCCCCCCCCC(C)C)=O—
2379-2lpmAM1
379-1;Aspartic acid
from: 379-1
OC([C@H](CC(O)=O)NC(/C=C/CCCCCCCCCC(C)C)=O)=O—
3379-3lpmBM2
379-2;diaminopropionic acid
from: 379-2
OC([C@@H](NC([C@H](CC(O)=O)NC(/C=C/CCCCCCCCCC(C)C)=O)=O)CN)=O—
4379-4lpmBM3
379-3;pipecolic acid
from: 379-3
O=C([C@@H](NC([C@H](CC(O)=O)NC(/C=C/CCCCCCCCCC(C)C)=O)=O)CN)N1CCCC[C@@H]1C(O)=O—
5379-5lpmCM4
379-4;Glycine
from: 379-4
O=C([C@@H](NC([C@H](CC(O)=O)NC(/C=C/CCCCCCCCCC(C)C)=O)=O)CN)N1CCCC[C@@H]1C(NCC(O)=O)=O—
6379-6lpmCM5
379-5;Aspartic acid
from: 379-5
O=C([C@@H](NC([C@H](CC(O)=O)NC(/C=C/CCCCCCCCCC(C)C)=O)=O)CN)N1CCCC[C@@H]1C(NCC(N[C@@H](CC(O)=O)C(O)=O)=O)=O—
7379-7lpmCM6
379-6;Glycine
from: 379-6
O=C([C@@H](NC([C@H](CC(O)=O)NC(/C=C/CCCCCCCCCC(C)C)=O)=O)CN)N1CCCC[C@@H]1C(NCC(N[C@@H](CC(O)=O)C(NCC(O)=O)=O)=O)=O—
8379-8lpmCM7
379-7Aspartic acid
from: 379-7Aspartic acid
O=C([C@@H](NC([C@H](CC(O)=O)NC(/C=C/CCCCCCCCCC(C)C)=O)=O)CN)N1CCCC[C@@H]1C(NCC(N[C@@H](CC(O)=O)C(NCC(N[C@H](C(O)=O)CC(O)=O)=O)=O)=O)=O—
9379-9lpmCM8
379-8;Glycine
from: 379-8
O=C([C@@H](NC([C@H](CC(O)=O)NC(/C=C/CCCCCCCCCC(C)C)=O)=O)CN)N1CCCC[C@@H]1C(NCC(N[C@@H](CC(O)=O)C(NCC(N[C@H](C(NCC(O)=O)=O)CC(O)=O)=O)=O)=O)=O—
10379-10lpmCM9
379-9;Threonine
from: 379-9
O=C([C@@H](NC([C@H](CC(O)=O)NC(/C=C/CCCCCCCCCC(C)C)=O)=O)CN)N1CCCC[C@@H]1C(NCC(N[C@@H](CC(O)=O)C(NCC(N[C@H](C(NCC(N[C@@]([C@@H](O)C)([H])C(O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O—
11379-11lpmDM10
379-10;Isoleucine
from: 379-10
O=C([C@@H](NC([C@H](CC(O)=O)NC(/C=C/CCCCCCCCCC(C)C)=O)=O)CN)N1CCCC[C@@H]1C(NCC(N[C@@H](CC(O)=O)C(NCC(N[C@H](C(NCC(N[C@@]([C@@H](O)C)([H])C(N[C@]([C@@H](C)CC)([H])C(O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O—
12379-12lpmDM11
379-11;Proline
from: 379-11
O=C([C@@H](NC([C@H](CC(O)=O)NC(/C=C/CCCCCCCCCC(C)C)=O)=O)CN)N1CCCC[C@@H]1C(NCC(N[C@@H](CC(O)=O)C(NCC(N[C@H](C(NCC(N[C@@]([C@@H](O)C)([H])C(N[C@]([C@@H](C)CC)([H])C(N(CCC2)[C@@H]2C(O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O—
13379lpmDTE
379-12
from: 379-12
O=C([C@@H](NC([C@H](CC(O)=O)NC(/C=C/CCCCCCCCCC(C)C)=O)=O)CNC([C@H]1N2CCC1)=O)N3CCCC[C@@H]3C(NCC(N[C@@H](CC(O)=O)C(NCC(N[C@H](C(NCC(N[C@@]([C@@H](O)C)([H])C(N[C@]([C@@H](C)CC)([H])C2=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O—
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