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BGC0000378NRPS

Kutzneride 1;Kutzneride 2;Kutzneride 3;Kutzneride 4;Kutzneride 5;Kutzneride 6;Kutzneride 7;Kutzneride 8

Producing organism
Kutzneria sp. 744
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Kutzneria
Biosynthetic class
NRPS (Type I)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗
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C37H49Cl2N7O12853.28 Da

Gene Cluster Map29 genes · 56,081 bp

ATauDTauDACAECACECAAAECA10 kb56.1 kb visible · 56,081 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
EEpimerization (E)
TauDTauD oxygenase
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1Load
ktzE
+2-(1-methylcyclop…
Step 2M1
ktzG
+2-keto-isovaleric…
Step 3M2
ktzH
+D-piperazic acid
Step 4M3
ktzH
+O-methyl-l-serine
Step 5M4
ktzH;ktzN
+Glutamic acid
Step 6
ktzO/ktzP
Step 7M5
ktzH
+(2S,3aR,8aS)-6,7,…
Step 8TE
ktzH,?
Step 9TE
ktzH,?
Step 10TE
ktzH,?
Step 11TE
ktzH,?
Step 12TE
ktzH,?
Step 13TE
ktzH,?
Step 14TE
ktzH,?
Step 15TE
ktzH,?
Step 16TE
ktzH,?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1378-1ktzELoading
2-(1-methylcyclopropyl)-D-glycine
OC([C@H](C1(CC1)C)N)=O—
2378-2ktzGM1
378-1;2-keto-isovaleric acid
from: 378-1
O=C(O[C@@H](CCCC)C(O)=O)[C@@H](C1(CC1)C)N—
3378-3ktzHM2
378-2;D-piperazic acid
from: 378-2
O=C(O[C@@H](CCCC)C(N1NC[C@H](Cl)C[C@H]1C(O)=O)=O)[C@@H](C2(CC2)C)N—
4378-4ktzHM3
378-3;O-methyl-l-serine
from: 378-3
O=C(O[C@@H](CCCC)C(N1NC[C@H](Cl)C[C@H]1C(N[C@H](C(O)=O)COC)=O)=O)[C@@H](C2(CC2)C)N—
5378-5ktzH;ktzNM4
378-4;Glutamic acid
from: 378-4
O=C(OC(C(C)(C)C)C(N1NCCC[C@H]1C(N[C@H](C(N[C@@H](CCC(O)=O)C(O)=O)=O)COC)=O)=O)[C@@H](C2(CC2)C)N—
6378-6ktzO/ktzP—
378-5
from: 378-5
O=C(OC(C(C)(C)C)C(N1NCCC[C@H]1C(N[C@H](C(N[C@@H](C(CC(O)=O)O)C(O)=O)=O)COC)=O)=O)[C@@H](C2(CC2)C)N—
7378-7ktzHM5
378-6;(2S,3aR,8aS)-6,7,dichloro-3a-hydroxy-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid
from: 378-6
O=C(OC(C(C)(C)C)C(N1NCCC[C@H]1C(N[C@H](C(N[C@@H](C(CC(O)=O)O)C(N[C@@H](CC2=CNC3=C2C=CC(Cl)=C3Cl)C(O)=O)=O)=O)COC)=O)=O)[C@@H](C4(CC4)C)N—
8378-8ktzH,?TE
378-7
from: 378-7
O=C(N[C@H](C(N[C@H](C(CC(O)=O)O)C(N1[C@@H](C[C@]2(O)C1NC3=C2C=CC(Cl)=C3Cl)C4=O)=O)=O)COC)[C@@H]5CC([R1])C([R2])N([R3])N5C(C(OC([C@@H](C6(CC6)C)N4)=O)C(C)([R4])C)=O—
9378(1)ktzH,?TE
378-7
from: 378-7
O=C(N[C@H](C(N[C@H]([C@H](CC(O)=O)O)C(N1[C@@H](C[C@]2(O)C1NC3=C2C=CC(Cl)=C3Cl)C4=O)=O)=O)COC)[C@@H]5CCCNN5C(C(OC([C@@H](C6(CC6)C)N4)=O)C(C)(C)C)=O—
10378(2)ktzH,?TE
378-7
from: 378-7
O=C(N[C@H](C(N[C@H]([C@H](CC(O)=O)O)C(N1[C@@H](C[C@]2(O)C1NC3=C2C=CC(Cl)=C3Cl)C4=O)=O)=O)COC)[C@@H]5CC(Cl)CNN5C(C(OC([C@@H](C6(CC6)C)N4)=O)C(C)(C)C)=O—
11378(3)ktzH,?TE
378-7
from: 378-7
O=C(N[C@H](C(N[C@H]([C@@H](CC(O)=O)O)C(N1[C@@H](C[C@]2(O)C1NC3=C2C=CC(Cl)=C3Cl)C4=O)=O)=O)COC)[C@@H]5CCCNN5C(C(OC([C@@H](C6(CC6)C)N4)=O)C(C)(C)C)=O—
12378(4)ktzH,?TE
378-7
from: 378-7
O=C(N[C@H](C(N[C@H]([C@@H](CC(O)=O)O)C(N1[C@@H](C[C@]2(O)C1NC3=C2C=CC(Cl)=C3Cl)C4=O)=O)=O)COC)[C@@H]5CCC=NN5C(C(OC([C@@H](C6(CC6)C)N4)=O)C(C)(C)C)=O—
13378(5)ktzH,?TE
378-7
from: 378-7
O=C(N[C@H](C(N[C@H]([C@@H](CC(O)=O)O)C(N1[C@@H](C[C@]2(O)C1NC3=C2C=CC(Cl)=C3Cl)C4=O)=O)=O)COC)[C@@H]5CCCNN5C(C(OC([C@@H](C6(CC6)C)N4)=O)C(C)C)=O—
14378(6)ktzH,?TE
378-7
from: 378-7
O=C(N[C@H](C(N[C@H]([C@@H](CC(O)=O)O)C(N1[C@@H](C[C@]2(O)C1NC3=C2C=CC(Cl)=C3Cl)C4=O)=O)=O)COC)[C@@H]5C[C@H](O)C=NN5C(C(OC([C@@H](C6(CC6)C)N4)=O)C(C)(C)C)=O—
15378(7)ktzH,?TE
378-7
from: 378-7
O=C(N[C@H](C(N[C@H]([C@H](CC(O)=O)O)C(N1[C@@H](C[C@]2(O)C1NC3=C2C=CC(Cl)=C3Cl)C4=O)=O)=O)COC)[C@@H]5CCCNN5C(C(OC([C@@H](C6(CC6)C)N4)=O)C(C)C)=O—
16378(8)ktzH,?TE
378-7
from: 378-7
O=C(N[C@H](C(N[C@H]([C@@H](CC(O)=O)O)C(N1[C@@H](C[C@]2(O)C1NC3=C2C=CC(Cl)=C3Cl)C4=O)=O)=O)COC)[C@@H]5CC(Cl)CNN5C(C(OC([C@@H](C6(CC6)C)N4)=O)C(C)(C)C)=O—
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