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BGC0000376NRPS

JBIR-34;JBIR-35

Producing organism
Streptomyces sp. Sp080513GE-23
Taxonomy
BacteriaActinomycetotaActinomycetesKitasatosporalesStreptomycetaceaeStreptomyces
Biosynthetic class
NRPS (Type I)
Total steps
12
DOI
MIBiG entry
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C21H25ClN4O7480.14 Da

Gene Cluster Map24 genes · 43,673 bp

AACyCyACACTETEABEL10 kb43.7 kb visible · 43,673 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
CyHeterocyclization (Cy)
BELBeta-elim. lyase

Pathway Graphsteps arranged in biosynthetic order

12 steps · 10 edges
Step 1
start
+Tryptophan
Step 2
fmoD
Step 3M1
fmoA1,fmoC,fmoB
+6-chloro-4-hydrox…
Step 4
fmoM,fmoI
Step 5M2
fmoA2, fmoH
+D-alanine
Step 6
fmoA3
Step 7
fmoA3
Step 8M3
fmoA4
+L-alanine
Step 9M4
fmoA5
+L-serine
Step 10TE
fmoA5
Step 11TE
fmoA5
Step 12TE
fmoA5
Starting stepIntermediateFinal productModuleLoadingTENo modulePKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions12 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1376-1start
Tryptophan
O=C(O)C(N)CC1=CNC2=C1C=CC=C2
2376-2fmoD
376-1
from: 376-1
O=C(O)C(N)CC1=CNC2=C1C=CC(Cl)=C2
3376-3fmoA1,fmoC,fmoBM1
376-2;6-chloro-4-hydroxyindole-3-carboxylic acid
from: 376-2
O=C(O)C(N)C(O)C1=CNC2=C1C(O)=CC(Cl)=C2
4376-4fmoM,fmoI
376-3
from: 376-3
OC(C1=CNC2=C1C(O)=CC(Cl)=C2)=O
5376-5fmoA2, fmoHM2
376-4;D-alanine
from: 376-4
ClC1=CC2=C(C(O)=C1)C(C(N[C@@](C)(CO)C(O)=O)=O)=CN2C
6376-6fmoA3
376-5
from: 376-5
ClC1=CC2=C(C(O)=C1)C(C(OC3)(O)N[C@]3(C)C(O)=O)=CN2
7376-7fmoA3
376-6
from: 376-6
ClC1=CC2=C(C(O)=C1)C(C(OC3)=N[C@]3(C)C(O)=O)=CN2
8376-8fmoA4M3
376-7;L-alanine
from: 376-7
ClC1=CC2=C(C(O)=C1[R])C(C(OC3)=N[C@]3(C)C(N[C@H](C)C(O)=O)=O)=CN2C
9376-9fmoA5M4
376-8;L-serine
from: 376-8
ClC1=CC2=C(C(O)=C1[R])C(C(OC3)=N[C@]3(C)C(N[C@@H](C)C(N[C@H](CO)C(O)=O)=O)=O)=CN2C
10376(1)fmoA5TE
376-9
from: 376-9
ClC1=CC2=C(C(O)=C1[R])C(C(OC3)=N[C@]3(C)C(N[C@H](C)C(N[C@@H](CO)C(O)=O)=O)=O)=CN2C
11376(1)fmoA5TE
376-9
from: 376-9
ClC1=CC2=C(C(O)=C1C)C(C(OC3)=N[C@]3(C)C(N[C@H](C)C(N[C@@H](CO)C(O)=O)=O)=O)=CN2C
12376(2)fmoA5TE
376-9
from: 376-9
ClC1=CC2=C(C(O)=C1)C(C(OC3)=N[C@]3(C)C(N[C@H](C)C(N[C@@H](CO)C(O)=O)=O)=O)=CN2C
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture