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BGC0000373NRPS

holomycin

Producing organism
Streptomyces clavuligerus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
9
DOI
MIBiG entry
View on MIBiG ↗
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holomycin
C7H6N2O2S2213.99 Da

Gene Cluster Map13 genes · 18,318 bp

TECyATEC5 kb18.3 kb visible · 18,318 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
CyHeterocyclization (Cy)

Pathway Graphsteps arranged in biosynthetic order

9 steps · 8 edges
Step 1Load
SCLAV_5271
+cysteine
Step 2M1
?
Step 3
SCLAV_5268
Step 4
SCLAV_5268
Step 5
spontaneous?
Step 6TE
SCLAV_5269
Step 7
SCLAV_5270
Step 8
SCLAV_5275
Step 9
SCLAV_5267
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions9 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1373-1SCLAV_5271Loading
cysteine
OC(C(CS)N)=O—
2373-2?M1
373-1
from: 373-1
SCC(N)C(NC(C(O)=O)CS)=O—
3373-3SCLAV_5268—
373-2
from: 373-2
S=CC(N)C(NC(C(O)=O)CS)=O—
4373-4SCLAV_5268—
373-3
from: 373-3
S=CC(N)C(N/C(C(O)=O)=C\S)=O—
5373-5spontaneous?—
373-4
from: 373-4
SC(C(C=S)(C(O)=O)N1)C(N)C1=O—
6373-6SCLAV_5269TE
373-5
from: 373-5
SC(/C(N1)=C\S)C(N)C1=O—
7373-7SCLAV_5270—
373-6
from: 373-6
SC(/C(NC1=O)=C\S)C1=N—
8373-8SCLAV_5275—
373-7
from: 373-7
O=C1NC2=CSSC2=C1N—
9373SCLAV_5267—
373-8
from: 373-8
O=C1NC2=CSSC2=C1NC(C)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture