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BGC0000371NRPS

heterobactin A;heterobactin S2

Producing organism
Rhodococcus erythropolis PR4
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Mycobacteriales›Nocardiaceae›Rhodococcus›Rhodococcus erythropolis group
Biosynthetic class
NRPS (Type I)
Total steps
8
DOI
MIBiG entry
View on MIBiG ↗
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C27H33N7O10615.23 Da

Gene Cluster Map11 genes · 22,529 bp

KRACAETgrCACATE5 kb22.5 kb visible · 22,529 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Other
Unknown
Domains
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
EEpimerization (E)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

8 steps · 7 edges
Step 1
start
+2,3-dihydroxybenz…
Step 4
Start
+L-Ornithine
Step 2M1
RER_27010
+Arginine
Step 5
?
Step 7TE
RER_27010
Step 3M2
RER_27010
+Glycine
Step 8
?
+371(1)
Step 6M3
RER_27010
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions8 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1371-1start—
2,3-dihydroxybenzoate
OC(C1=CC=CC(O)=C1O)=O—
2371-2RER_27010M1
371-1;Arginine
from: 371-1
OC([C@@H](CCCN/C(N)=N/C(C1=C(C(O)=CC=C1)O)=O)NC(C2=CC=CC(O)=C2O)=O)=O—
3371-3RER_27010M2
371-2;Glycine
from: 371-2
O=C(CNC([C@@H](CCCN/C(N)=N/C(C1=C(C(O)=CC=C1)O)=O)NC(C2=CC=CC(O)=C2O)=O)=O)O—
4371-4Start—
L-Ornithine
N[C@H](C(O)=O)CCCN—
5371-5?—
371-4
from: 371-4
N[C@H](C(O)=O)CCCNO—
6371-6RER_27010M3
371-3;371-5
from: 371-3, 371-5
O=C(CNC([C@@H](CCCN/C(N)=N/C(C1=C(C(O)=CC=C1)O)=O)NC(C2=CC=CC(O)=C2O)=O)=O)N[C@H](C(O)=O)CCCNO—
7371(1)RER_27010TE
371-4
from: 371-4
O=C(CNC([C@@H](CCCN/C(N)=N/C(C1=C(C(O)=CC=C1)O)=O)NC(C2=CC=CC(O)=C2O)=O)=O)N[C@H]3CCCN(O)C3=O—
8371(2)?—
371(1)
O=C(CNC([C@@H](CCCN/C(N)=N/C(C1=C(C(O)=CC=C1)O)=O)NC(C2=CC=C(S(=O)(O)=O)C(O)=C2O)=O)=O)N[C@H]3CCCN(O)C3=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture