NPdia

BGC0000365NRPS

glycopeptidolipid

Producing organism: Mycolicibacterium smegmatis MC2 155
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Mycobacteriales›Mycobacteriaceae›Mycolicibacterium
Biosynthetic class: NRPS (Type I)
Total steps: 10
DOI: 10.1074/jbc.M112.384966
MIBiG entry: View on MIBiG ↗

Biosynthetic (core)

Biosynthetic (additional)

Transport

Other

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Dehydratase (DH)

Enoylreductase (ER)

Ketoreductase (KR)

Acyl carrier (ACP)

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

Epimerization (E)

Methyltransferase

Terminal reductase

CoA-ligase (CAL)

NAD-binding

TIGR01720

10 steps · 9 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`365-1`	start	—	?	`[R]CCCC(O)=O`	—
2	`365-2`	pks	M1	365-1;malonyl-CoA from: 365-1	`[R]CCCC(O)CC(O)=O`	—
3	`365-3`	pks	M2	365-2;malonyl-CoA from: 365-2	`[R]CCCC(O)CCCC(O)=O`	—
4	`365-4`	mps1	M1	365-3;Phenylalalnine from: 365-3	`[R]CCCC(O)CCCC(NC(CC1=CC=CC=C1)C(O)=O)=O`	—
5	`365-5`	mps1	M2	365-4;Threonine from: 365-4	`[R]CCCC(O)CCCC(NC(CC1=CC=CC=C1)C(NC(C(O)C)C(O)=O)=O)=O`	—
6	`365-6`	mps2	M3	365-5;Alanine from: 365-5	`[R]CCCC(O)CCCC(NC(CC1=CC=CC=C1)C(NC(C(O)C)C(NC(C)C(O)=O)=O)=O)=O`	—
7	`365-7`	mps2	M4	365-6;alaninol from: 365-6	`[R]CCCC(O)CCCC(NC(CC1=CC=CC=C1)C(NC(C(O)C)C(NC(C)C(NC(C)C(O)=O)=O)=O)=O)=O`	—
8	`365-8`	Start	—	6-deoxytalose	`O[C@H]1[C@H](O)[C@H](O)C(O)[C@H](C)O1`	—
9	`365-9`	Start	—	3,4-di-O-methyl rhamnose	`O[C@H]1[C@H](O)[C@H](OC)[C@@H](OC)[C@H](C)O1`	—
10	`365`	?	—	365-7;365-8;365-9 from: 365-7, 365-8, 365-9	`[R]CCCC(O)CCCC(NC(CC1=CC=CC=C1)C(NC(C(O[C@H]2[C@H](O)[C@H](O)C(O)[C@H](C)O2)C)C(NC(C)C(NC(C)CO[C@H]3[C@H](O)[C@H](OC)[C@@H](OC)[C@H](C)O3)=O)=O)=O)=O`	—

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