NPdia

BGC0000360NRPS

GE81112

Producing organism: Streptomyces sp. L-49973
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I)
Total steps: 12
DOI: 10.1074/jbc.m110.146803
MIBiG entry: View on MIBiG ↗

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GE81112

C₂₄H₃₅ClN₁₀O₁₀658.22 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Transport

Unknown

Domains

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

Acyl carrier (ACP)

Thioesterase (TE)

TauD oxygenase

12 steps · 11 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`360-1`	start	—	(2S)-Lysine	`N[C@H](C(O)=O)CCCCN`	—
2	`360-2`	getD	—	360-1 from: 360-1	`O=C([C@H]1NCCCC1)O`	—
3	`360-3`	getF	—	360-2 from: 360-2	`O[C@@H]1[C@@H](C(O)=O)NCCC1`	—
4	`360-4`	getE;getH	M1	360-3 from: 360-3	`O[C@H]1CCCN[C@H]1C(O)=O`	—
5	`360-5`	getH	M2	360-4;(2S)-5-hydroxy-2-aminopentanoic acid from: 360-4	`O=C(N[C@H](C(O)=O)C[C@H](CO)O)[C@H]1NCCC[C@@H]1O`	—
6	`360-6`	getH	M3	360-5;(2S)-Histidine from: 360-5	`O=C(N[C@H](C(N[C@@H](CC1=CN=CN1)C(O)=O)=O)C[C@H](CO)O)[C@H]2NCCC[C@@H]2O`	—
7	`360-7`	Start	—	(2S)-Histidine	`O=C(O)[C@@H](N)CC1=CN=CN1`	—
8	`360-8`	getM	—	360-7 from: 360-7	`O=C(O)[C@@H](N)CC1=CN=CN1`	—
9	`360-9`	getL	—	360-8 from: 360-8	`O=C(O)[C@@H](N)CC1=CN=C(Cl)N1`	—
10	`360-10`	getA	TE	360-9 from: 360-9	`O=C(O)[C@@H](N)CC1=CN=C(Cl)N1`	—
11	`360-11`	getH;getJ;getI	M4	360-6;360-10 from: 360-6, 360-10	`O=C(N[C@H](C(N[C@@H](CC1=CN=CN1)C(N[C@H](C(O)=O)[C@@H](C2=CN=C(Cl)N2)O)=O)=O)C[C@H](CO)O)[C@H]3NCCC[C@@H]3O`	—
12	`360`	thioesterase	TE	360-7 from: 360-7	`O=C(N[C@H](C(N[C@@H](CC1=CN=CN1)C(N[C@H](C(O)=O)[C@@H](C2=CN=C(Cl)N2)O)=O)=O)C[C@H](COC(N)=O)O)[C@H]3NCCC[C@@H]3O`	—

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