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BGC0000359NRPS

Fuscachelin A;Fuscachelin B;Fuscachelin C

Producing organism
Thermobifida fusca YX
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Streptosporangiales›Nocardiopsaceae›Thermobifida
Biosynthetic class
NRPS (Type I)
Total steps
10
DOI
MIBiG entry
View on MIBiG ↗
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C42H59N15O161029.43 Da

Gene Cluster Map9 genes · 24,159 bp

CATECACAETgrCACAAKR5 kb24.2 kb visible · 24,159 bp total
Biosynthetic (core)
Biosynthetic (additional)
Domains
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
EEpimerization (E)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

10 steps · 10 edges
Step 1M1
Tfu_1871
+2,3-dihydroxybenz…
Step 2M2
Tfu_1867
+Arginine
Step 3M3
Tfu_1867
+Glycine
Step 4M4
Tfu_1867
+Glycine
Step 5M5
Tfu_1866
+Serine
Step 6M6
Tfu_1865
+L-N_x0002_-hydrox…
Step 7M7
Tfu_1865
Step 8TE
Tfu_1865
Step 9
?
+359(1)
Step 10
?
+359(2)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions10 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1359-1Tfu_1871M1
2,3-dihydroxybenzoic acid
OC(C1=CC=CC(O)=C1O)=O—
2359-2Tfu_1867M2
359-1;Arginine
from: 359-1
OC(C(CCCNC(N)=N)NC(C1=CC=CC(O)=C1O)=O)=O—
3359-3Tfu_1867M3
359-2;Glycine
from: 359-2
OC(CNC(C(CCCNC(N)=N)NC(C1=CC=CC(O)=C1O)=O)=O)=O—
4359-4Tfu_1867M4
359-3;Glycine
from: 359-3
OC(CNC(CNC(C(CCCNC(N)=N)NC(C1=CC=CC(O)=C1O)=O)=O)=O)=O—
5359-5Tfu_1866M5
359-4;Serine
from: 359-4
OC(C(CO)NC(CNC(CNC(C(CCCNC(N)=N)NC(C1=CC=CC(O)=C1O)=O)=O)=O)=O)=O—
6359-6Tfu_1865M6
359-5;L-N_x0002_-hydroxyornithine
from: 359-5
O=C(O)C([NH3+])CCCN(O)C(C(CO)NC(CNC(CNC(C(CCCNC(N)=N)NC(C1=CC=CC(O)=C1O)=O)=O)=O)=O)=O—
7359-7Tfu_1865M7
359-6;359-4
from: 359-6, 359-4
O=C1[C@@H](NC(CNC(CNC([C@@H](CCCNC(N)=N)NC(C2=CC=CC(O)=C2O)=O)=O)=O)=O)COC([C@@H](NC(CNC(CNC([C@@H](CCCNC(N)=N)NC(C3=CC=CC(O)=C3O)=O)=O)=O)=O)CCCN1O)=O—
8359(1)Tfu_1865TE
359-7
from: 359-7
O=C1[C@@H](NC(CNC(CNC([C@@H](CCCNC(N)=N)NC(C2=CC=CC(O)=C2O)=O)=O)=O)=O)COC([C@@H](NC(CNC(CNC([C@@H](CCCNC(N)=N)NC(C3=CC=CC(O)=C3O)=O)=O)=O)=O)CCCN1O)=O—
9359(2)?—
359(1)
OC([C@@H](NC(CNC(CNC([C@@H](CCCNC(N)=N)NC(C1=CC=CC(O)=C1O)=O)=O)=O)=O)CCCN(O)C([C@@H](NC(CNC(CNC([C@@H](CCCNC(N)=N)NC(C2=CC=CC(O)=C2O)=O)=O)=O)=O)CO)=O)=O—
10359(3)?—
359(2)
NC([C@@H](NC(CNC(CNC([C@@H](CCCNC(N)=N)NC(C1=CC=CC(O)=C1O)=O)=O)=O)=O)CCCN(O)C([C@@H](NC(CNC(CNC([C@@H](CCCNC(N)=N)NC(C2=CC=CC(O)=C2O)=O)=O)=O)=O)CO)=O)=O—
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