NPdia

BGC0000346Hybrid

epoxomicin

Producing organism: Goodfellowiella coeruleoviolacea
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Goodfellowiella
Biosynthetic class: NRPS (Type I);PKS (Type 1)
Total steps: 8
DOI: 10.1021/cb400699p
MIBiG entry: View on MIBiG ↗

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epoxomicin

C₂₈H₅₀N₄O₇554.37 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

Thioesterase (TE)

Methyltransferase

8 steps · 7 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`346-1`	start	—	Acetyl-CoA	`OC(C)=O`	—
2	`346-2`	epxD	M1	346-1;Isoleucine from: 346-1	`CC(N(C)[C@H]([C@@H](C)CC)C(O)=O)=O`	—
3	`346-3`	epxD	M2	346-2;Isoleucine from: 346-2	`CC(N(C)[C@H]([C@@H](C)CC)C(N[C@@H]([C@H](CC)C)C(O)=O)=O)=O`	—
4	`346-4`	epxD	M3	346-3;Threonine from: 346-3	`CC(N(C)[C@H]([C@@H](C)CC)C(N[C@@H]([C@H](CC)C)C(N[C@H]([C@@H](C)O)C(O)=O)=O)=O)=O`	—
5	`346-5`	epxD	M4	346-4;Leucine from: 346-4	`CC(N(C)[C@H]([C@@H](C)CC)C(N[C@@H]([C@H](CC)C)C(N[C@H]([C@@H](C)O)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O`	—
6	`346-6`	epxE	M5	346-5;malonyl-CoA from: 346-5	`CC(N(C)[C@H]([C@@H](C)CC)C(N[C@@H]([C@H](CC)C)C(N[C@H]([C@@H](C)O)C(N[C@@H](CC(C)C)C(C(C)C(O)=O)=O)=O)=O)=O)=O`	—
7	`346-7`	epxE	TE	346-6 from: 346-6	`CC(N(C)[C@H]([C@@H](C)CC)C(N[C@@H]([C@H](CC)C)C(N[C@H]([C@@H](C)O)C(N[C@@H](CC(C)C)C(C(C)C(O)=O)=O)=O)=O)=O)=O`	—
8	`346`	?	—	346-7 from: 346-7	`CC(N(C)[C@H]([C@@H](C)CC)C(N[C@@H]([C@H](CC)C)C(N[C@H]([C@@H](C)O)C(N[C@@H](CC(C)C)C(C1(CO1)C)=O)=O)=O)=O)=O`	—

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