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BGC0000345Hybrid

eponemycin

Producing organism
Streptomyces hygroscopicus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces violaceusniger group
Biosynthetic class
NRPS (Type I);PKS (Type 1)
Total steps
8
DOI
MIBiG entry
View on MIBiG ↗
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eponemycin
C20H34N2O6398.24 Da

Gene Cluster Map14 genes · 25,783 bp

TECACAKSATMTA5 kb25.8 kb visible · 25,783 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

8 steps · 7 edges
Step 1
epnJ
+Isoleucine
Step 2Load
epnJ
Step 3M1
epnD,epnE
+Malonyl-CoA
Step 4M2
epnG
+Serine
Step 5M3
epnH
+Leucine
Step 6M4
epnH
+malonyl-CoA
Step 7TE
epnH
Step 8
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions8 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1345-1epnJ—
Isoleucine
CC(C)CC(N)C(O)=O—
2345-2epnJLoading
345-1
from: 345-1
CC(C)CCC(O)=O—
3345-3epnD,epnEM1
345-2;Malonyl-CoA
from: 345-2
CC(C)CCCCC(O)=O—
4345-4epnGM2
345-3;Serine
from: 345-3
CC(C)CCCCC(N[C@@H](CO)C(O)=O)=O—
5345-5epnHM3
345-4;Leucine
from: 345-4
CC(C)CCCCC(N[C@@H](CO)C(N[C@@H](CC(C)=C)C(O)=O)=O)=O—
6345-6epnHM4
345-5;malonyl-CoA
from: 345-5
CC(C)CCCCC(N[C@@H](CO)C(N[C@@H](CC(C)=C)C(C(C)C(O)=O)=O)=O)=O—
7345-7epnHTE
345-6
from: 345-6
CC(C)CCCCC(N[C@@H](CO)C(N[C@@H](CC(C)=C)C(C(C)C(O)=O)=O)=O)=O—
8345?—
345-7
from: 345-7
CC(C)CCCCC(N[C@@H](CO)C(N[C@@H](CC(C)=C)C(C1(CO1)CO)=O)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture