NPdia

BGC0000340NRPS

echoside A;echoside B;echoside C;echoside D;echoside E

Producing organism: Streptomyces sp. LZ35
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I)
Total steps: 10
DOI: 10.1016/j.gene.2014.05.053
MIBiG entry: View on MIBiG ↗

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C₂₅H₂₄O₉468.14 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Transport

Unknown

Domains

Enoylreductase (ER)

Ketoreductase (KR)

Adenylation (A)

Peptidyl carrier (PCP)

Thioesterase (TE)

NAD-binding

10 steps · 9 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`340-1`	start	—	L-Phenylalanine	`OC(C(N)CC1=CC=CC=C1)=O`	—
2	`340-2`	?	—	340-1 from: 340-1	`O=C(C(O)=O)CC1=CC=CC=C1`	—
3	`340-3`	echA	—	340-2;340-2 from: 340-2, 340-2	`O=C(C(C1=CC=CC=C1)=C2O)C(O)=C(C3=CC=CC=C3)C2=O`	—
4	`340-4`	echB,echC	—	340-2 from: 340-2	`OC1=C(C(O)=C(O)C(C2=CC=CC=C2)=C1)C3=CC=CC=C3`	—
5	`340-5`	Start	—	Glucuronic acid	`O[C@@H]1[C@H](O)[C@@H](C(O)=O)O[C@@H](O)[C@@H]1O`	—
6	`340(1)`	?	—	340-4;340-5 from: 340-4, 340-5	`OC1=C(C(O)=C(O[C@H]2[C@H](O)[C@H](O)[C@H](O)[C@@H](C(O)=O)O2)C(C3=CC=CC=C3)=C1)C4=CC=CC=C4`	—
7	`340(2)`	?	—	340(1)	`OC1=C(C(O)=C(O[C@H]2[C@H](O)[C@H](O)[C@H](O)[C@@H](C(OC)=O)O2)C(C3=CC=CC=C3)=C1)C4=CC=CC=C4`	—
8	`340(3)`	?	—	340(1)	`O[C@H]1[C@@H](O)[C@H](C(OC)=O)O[C@H](OC2=CC(C3=CC=CC=C3)=C(OC)C(O)=C2C4=CC=CC=C4)[C@H]1O`	—
9	`340(4)`	?	—	340(1)	`OC1=C(C2=CC=CC=C2)C3=C(N=CS3)C(C4=CC=CC=C4)=C1OC5[C@H](O)[C@H](O)[C@H](O)[C@@H](C(O)=O)O5`	—
10	`340(5)`	?	—	340(1)	`OC1=C(C2=CC=CC=C2)C(SC3=O)=C(N3C)C(C4=CC=CC=C4)=C1OC5[C@H](O)[C@H](O)[C@H](O)[C@@H](C(O)=O)O5`	—

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