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BGC0000327NRPS

netropsin

Producing organism
Streptomyces ambofaciens ATCC 23877
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
9
DOI
MIBiG entry
View on MIBiG ↗
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netropsin
C18H26N10O3430.22 Da

Gene Cluster Map22 genes · 29,143 bp

ACCAmTNADCA5 kb29.1 kb visible · 29,143 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
AmTAminotransferase I/II
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

9 steps · 9 edges
Step 1
Start
+4-Amino-1H-pyrrol…
Step 4
Start
+Glycocyamine
Step 7
Start
+3-Aminopropanimid…
Step 2
SAMR0901
Step 5
SAMR0921
Step 3
SAMR0900
Step 6
SAMR0917/SAMR0903
Step 8
SAMR0917/SAMR0903
Step 9
SAMR0904
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions9 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1327-1Start—
4-Amino-1H-pyrrole-2-carboxylic acid
NC1=CNC(C(O)=O)=C1—
2327-2SAMR0901—
327-1
from: 327-1
NC1=CNC(C(O)=O)=C1—
3327-3SAMR0900—
327-2;327-1
from: 327-2, 327-1
NC1=CNC(C(NC2=CNC(C(O)=O)=C2)=O)=C1—
4327-4Start—
Glycocyamine
OC(CNC(N)=N)=O—
5327-5SAMR0921—
327-4
from: 327-4
[R]C(CNC(N)=N)=O—
6327-6SAMR0917/SAMR0903—
327-3;327-5
from: 327-3, 327-5
O=C(CNC(N)=N)NC1=CNC(C(NC2=CNC(C(O)=O)=C2)=O)=C1—
7327-7Start—
3-Aminopropanimidamide
N=C(CCN)N—
8327-8SAMR0917/SAMR0903—
327-6;327-7
from: 327-6, 327-7
O=C(CNC(N)=N)NC1=CNC(C(NC2=CNC(C(NCCC(N)=N)=O)=C2)=O)=C1—
9327SAMR0904—
327-8
from: 327-8
O=C(CNC(N)=N)NC1=CN(C)C(C(NC2=CN(C)C(C(NCCC(N)=N)=O)=C2)=O)=C1—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture