NPdia
← Back to Repository
BGC0000324NRPS

coelibactin

Producing organism
Streptomyces coelicolor A3(2)
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces albidoflavus group
Biosynthetic class
NRPS (Type I)
Total steps
7
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map11 genes · 25,121 bp

ACyACyACyAMTTETE5 kb25.1 kb visible · 25,121 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Other
Unknown
Domains
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
CyHeterocyclization (Cy)
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

7 steps · 6 edges
Step 1
Start
+Chrosimate
Step 2
?
Step 3Load
SCO7681
Step 4M1
SCO7682
+?
Step 5M2
SCO7682
+Homocysteine
Step 6M3
SCO7683
+Homocysteine
Step 7TE
SCO7683, ?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions7 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1324-1Start—
Chrosimate
OC(C1=CC(OC(C(O)=O)=C)C(O)C=C1)=O—
2324-2?—
324-1
from: 324-1
OC(C1=CC=CC=C1O)=O—
3324-3SCO7681Loading
324-2
from: 324-2
OC(C1=CC=CC=C1O)=O—
4324-4SCO7682M1
324-3;?
from: 324-3
O=C(O)C(C(C)O1)N=C1C2=CC=CC=C2O—
5324-5SCO7682M2
324-4;Homocysteine
from: 324-4
OC(C1CSC(C(C(C)O2)N=C2C3=CC=CC=C3O)=N1)=O—
6324-6SCO7683M3
324-5;Homocysteine
from: 324-5
O=C(O)C(CS1)N=C1C2CSC(C(C(C)O3)N=C3C4=CC=CC=C4O)=N2—
7324SCO7683, ?TE
324-6
from: 324-6
O=C(O)C(CS1)N=C1C2CSC(C(C(C)O3)N=C3C4=CC=CC=C4O)=N2—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture