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BGC0000322NRPS

chloroeremomycin

Producing organism
Amycolatopsis orientalis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Amycolatopsis
Biosynthetic class
NRPS (Type I)
Total steps
11
DOI
MIBiG entry
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chloroeremomycin
C73H88Cl2N10O261590.52 Da

Gene Cluster Map9 genes · 34,244 bp

ACAECACAECAECACAXTE5 kb34.2 kb visible · 34,244 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
XPutative domain (X)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

11 steps · 10 edges
Step 1M1
CAA11794.1
+Leucine
Step 9
Start
+Vancosamine
Step 10
Start
+Glucose
Step 2M2
CAA11794.1
+beta-hydroxytyros…
Step 3M3
CAA11794.1
+asparagine
Step 4M4
CAA11795.1
+hydroxyphenylglyc…
Step 5M5
CAA11795.1
+hydroxyphenylglyc…
Step 6M6
CAA11795.1,?
+beta-hydroxytyros…
Step 7M7
CAA11796.1
+3,5-dihydroxyphen…
Step 8TE
CAA11796.1
Step 11
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1322-1CAA11794.1M1
Leucine
OC([C@@](NC)([H])CC(C)C)=O—
2322-2CAA11794.1M2
322-1;beta-hydroxytyrosine
from: 322-1
OC1=CC=C([C@@H](O)[C@@H](NC([C@@](NC)([H])CC(C)C)=O)C(O)=O)C=C1—
3322-3CAA11794.1M3
322-2;asparagine
from: 322-2
OC1=CC=C([C@@H](O)[C@@H](NC([C@@](NC)([H])CC(C)C)=O)C(N[C@](CC(N)=O)([H])C(O)=O)=O)C=C1—
4322-4CAA11795.1M4
322-3;hydroxyphenylglycine
from: 322-3
OC1=CC=C([C@@](C(O)=O)([H])NC([C@@](CC(N)=O)([H])NC([C@H](NC([C@@](NC)([H])CC(C)C)=O)[C@H](O)C2=CC=C(O)C=C2)=O)=O)C=C1—
5322-5CAA11795.1M5
322-4;hydroxyphenylglycine
from: 322-4
OC1=CC=C([C@@](C(N[C@@](C2=CC=C(O)C=C2)([H])C(O)=O)=O)([H])NC([C@@](CC(N)=O)([H])NC([C@H](NC([C@@](NC)([H])CC(C)C)=O)[C@H](O)C(C=C3)=CC=C3O)=O)=O)C=C1—
6322-6CAA11795.1,?M6
322-5;beta-hydroxytyrosine
from: 322-5
OC1=C(Cl)C=C([C@@H](O)[C@](C(O)=O)([H])NC([C@](C2=CC=C(O)C=C2)([H])NC([C@@](NC([C@@](CC(N)=O)([H])NC([C@H](NC([C@@](NC)([H])CC(C)C)=O)[C@H](O)C(C=C3)=CC=C3O)=O)=O)([H])C4=CC=C(O)C=C4)=O)=O)C=C1—
7322-7CAA11796.1M7
322-6;3,5-dihydroxyphenylglycine
from: 322-6
OC1=C(Cl)C=C([C@@H](O)[C@](C(N[C@]([H])(C(O)=O)C2=CC(O)=CC(O)=C32)=O)([H])NC([C@](C4=CC=C(O)C3=C4)([H])NC([C@@](NC([C@@](CC(N)=O)([H])NC([C@H](NC([C@@](NC)([H])CC(C)C)=O)[C@H](O)C5=CC=CC(Cl)=C5)=O)=O)([H])C6=CC(O)=C(O)C=C6)=O)=O)C=C1—
8322-8CAA11796.1TE
322-7
from: 322-7
OC1=C(OC2=CC=C([C@@H](O)[C@@H](NC([C@@](NC)([H])CC(C)C)=O)C(N[C@@]3([H])CC(N)=O)=O)C=C2Cl)C=C([C@@](C(NC4([H])C5=CC=C(O)C6=C5)=O)([H])NC3=O)C=C1OC7=C(Cl)C=C([C@@H](O)[C@](C(N[C@]([H])(C(O)=O)C8=CC(O)=CC(O)=C68)=O)([H])NC4=O)C=C7—
9322-9Start—
Vancosamine
OC1[C@H](C)OC(O)C[C@@]1(N)C—
10322-10Start—
Glucose
O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O—
11322?—
322-8;322-9;322-10
from: 322-8, 322-9, 322-10
O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=C(OC3=CC=C([C@@H](O)[C@@H](NC([C@@](NC)([H])CC(C)C)=O)C(N[C@@]4([H])CC(N)=O)=O)C=C3Cl)C=C([C@@](C(NC5([H])C6=CC=C(O)C7=C6)=O)([H])NC4=O)C=C2OC8=C(Cl)C=C([C@@H](OC9O[C@@H](C)C(O)[C@@](C)(N)C9)[C@](C(N[C@]([H])(C(O)=O)C%10=CC(O)=CC(O)=C7%10)=O)([H])NC5=O)C=C8)[C@@H]1O[C@H]%11O[C@@H](C)C(O)[C@@](C)(N)C%11—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture