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BGC0000316NRPS

capreomycin 1A;capreomycin 1B;capreomycin 2A;capreomycin 2B

Producing organism
Saccharothrix mutabilis subsp. capreolus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Saccharothrix
Biosynthetic class
NRPS (Type I)
Total steps
10
DOI
MIBiG entry
View on MIBiG ↗
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C25H44N14O8668.35 Da

Gene Cluster Map32 genes · 44,141 bp

CACACAmTACATECCA10 kb44.1 kb visible · 44,141 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

10 steps · 9 edges
Step 1M1
cmnA
+L-2,3-diaminoprop…
Step 2M2
cmnA
+(L-Serine/L-Alani…
Step 3M3
cmnI
+L-2,3-diaminoprop…
{'Missing':['A'], 'Domain_…
Step 4M4
cmnF
+β-ureidodehydroal…
Step 5M5
cmnG
+L-capreomycidine
Step 6
?
Step 7
?
Step 8
?
Step 9
cmnO
+316(1), beta-Lysine
Step 10
cmnO
+316(2), beta-Lysine
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions10 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1316-1cmnAM1
L-2,3-diaminopropionic acid
NC[C@H](N)C(O)=O—
2316-2cmnAM2
316-1;(L-Serine/L-Alanine)
from: 316-1
NC[C@H](N)C(N[C@@H](C[R])C(O)=O)=O—
3316-3cmnIM3
316-2;L-2,3-diaminopropionic acid
from: 316-2
NC[C@H](N)C(N[C@@H](C[R])C(N[C@@H](CN)C(O)=O)=O)=O{'Missing':['A'], 'Domain_Re…
4316-4cmnFM4
316-3;β-ureidodehydroalanine
from: 316-3
NC[C@H](N)C(N[C@@H](C[R])C(N[C@@H](CN)C(N/C(C(O)=O)=C\NC(N)=O)=O)=O)=O—
5316-5cmnGM5
316-4;L-capreomycidine
from: 316-4
NC[C@H](N)C(N[C@@H](C[R])C(N[C@@H](CN)C(N/C(C(N[C@H](C(O)=O)[C@@H](CCN1)NC1=N)=O)=C\NC(N)=O)=O)=O)=O—
6316-6?—
316-5
from: 316-5
O=C(N[C@@H](CN)C(N/C1=C\NC(N)=O)=O)[C@H](C[R])NC([C@@H](N)CNC([C@H]([C@@H](CCN2)NC2=N)NC1=O)=O)=O—
7316(1)?—
316-5
from: 316-5
O=C(N[C@@H](CN)C(N/C1=C\NC(N)=O)=O)[C@H](CO)NC([C@@H](N)CNC([C@H]([C@@H](CCN2)NC2=N)NC1=O)=O)=O—
8316(2)?—
316-5
from: 316-5
O=C(N[C@@H](CN)C(N/C1=C\NC(N)=O)=O)[C@H](C[H])NC([C@@H](N)CNC([C@H]([C@@H](CCN2)NC2=N)NC1=O)=O)=O—
9316(3)cmnO—
316(1);beta-Lysine
O=C(N[C@@H](CNC(CC(N)CCCN)=O)C(N/C1=C\NC(N)=O)=O)[C@H](CO)NC([C@@H](N)CNC([C@H]([C@@H](CCN2)NC2=N)NC1=O)=O)=O—
10316(4)cmnO—
316(2);beta-Lysine
O=C(N[C@@H](CNC(CC(N)CCCN)=O)C(N/C1=C\NC(N)=O)=O)[C@H](C[H])NC([C@@H](N)CNC([C@H]([C@@H](CCN2)NC2=N)NC1=O)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture