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BGC0000311NRPS

balhimycin

Producing organism
Amycolatopsis balhimycina DSM 5908
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Amycolatopsis
Biosynthetic class
NRPS (Type I)
Total steps
11
DOI
MIBiG entry
View on MIBiG ↗
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balhimycin
C66H73Cl2N9O241445.41 Da

Gene Cluster Map37 genes · 66,669 bp

AAAAAAAAmTACAL10 kb66.7 kb visible · 66,669 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Resistance
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
ECHEnoyl-CoA hydratase
CALCoA-ligase (CAL)
AmTAminotransferase I/II
XPutative domain (X)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

11 steps · 10 edges
Step 1M1
bpsA
+N-methyl-Leucine
Step 9
Start
+Vancosamine
Step 10
Start
+Glucose
Step 2M2
bpsA
+beta-hydroxytyros…
Step 3M3
bpsA
+asparagine
Step 4M4
bpsB
+hydroxyphenylglyc…
Step 5M5
bpsB
+hydroxyphenylglyc…
Step 6M6
bpsB,?
+beta-hydroxytyros…
Step 7M7
bpsC
+3,5-dihydroxyphen…
Step 8TE
bpsC
Step 11
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
1311-1bpsAM1
N-methyl-Leucine
OC([C@@](NC)([H])CC(C)C)=O—
2311-2bpsAM2
311-1;beta-hydroxytyrosine
from: 311-1
OC1=CC=C([C@@H](O)[C@@H](NC([C@@](NC)([H])CC(C)C)=O)C(O)=O)C=C1—
3311-3bpsAM3
311-2;asparagine
from: 311-2
OC1=CC=C([C@@H](O)[C@@H](NC([C@@](NC)([H])CC(C)C)=O)C(N[C@](CC(N)=O)([H])C(O)=O)=O)C=C1—
4311-4bpsBM4
311-3;hydroxyphenylglycine
from: 311-3
OC1=CC=C([C@@](C(O)=O)([H])NC([C@@](CC(N)=O)([H])NC([C@H](NC([C@@](NC)([H])CC(C)C)=O)[C@H](O)C(C=C2)=CC=C2O)=O)=O)C=C1—
5311-5bpsBM5
311-4;hydroxyphenylglycine
from: 311-4
OC1=CC=C([C@@](C(N[C@@](C2=CC=C(O)C=C2)([H])C(O)=O)=O)([H])NC([C@@](CC(N)=O)([H])NC([C@H](NC([C@@](NC)([H])CC(C)C)=O)[C@H](O)C(C=C3)=CC=C3O)=O)=O)C=C1—
6311-6bpsB,?M6
311-5;beta-hydroxytyrosine
from: 311-5
OC1=C(Cl)C=C([C@@H](O)[C@](C(O)=O)([H])NC([C@](C2=CC=C(O)C=C2)([H])NC([C@@](NC([C@@](CC(N)=O)([H])NC([C@H](NC([C@@](NC)([H])CC(C)C)=O)[C@H](O)C(C=C3)=CC=C3O)=O)=O)([H])C4=CC=C(O)C=C4)=O)=O)C=C1—
7311-7bpsCM7
311-6;3,5-dihydroxyphenylglycine
from: 311-6
OC1=C(Cl)C=C([C@@H](O)[C@](C(N[C@]([H])(C(O)=O)C2=CC(O)=CC(O)=C2)=O)([H])NC([C@](C3=CC=C(O)C=C3)([H])NC([C@@](NC([C@@](CC(N)=O)([H])NC([C@H](NC([C@@](NC)([H])CC(C)C)=O)[C@H](O)C(C=C4)=CC=C4O)=O)=O)([H])C5=CC=C(O)C=C5)=O)=O)C=C1—
8311-8bpsCTE
311-7
from: 311-7
OC1=C(OC2=CC=C([C@@H](O)[C@@H](NC([C@@](NC)([H])CC(C)C)=O)C(N[C@@]3([H])CC(N)=O)=O)C=C2)C=C([C@@](C(NC4([H])C5=CC=C(O)C6=C5)=O)([H])NC3=O)C=C1OC7=C(Cl)C=C([C@@H](O)[C@](C(N[C@]([H])(C(O)=O)C8=CC(O)=CC(O)=C86)=O)([H])NC4=O)C=C7—
9311-9Start—
Vancosamine
OC1[C@H](C)OC(O)C[C@@]1(N)C—
10311-10Start—
Glucose
O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O—
11311?—
311-8;311-9;311-10
from: 311-8, 311-9, 311-10
O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC2=C(OC3=CC=C([C@@H](O)[C@@H](NC([C@@](NC)([H])CC(C)C)=O)C(N[C@@]4([H])CC(N)=O)=O)C=C3Cl)C=C([C@@](C(NC5([H])C6=CC=C(O)C7=C6)=O)([H])NC4=O)C=C2OC8=C(Cl)C=C([C@@H](OC(C[C@@]9(N)C)O[C@@H](C)C9=O)[C@](C(N[C@]([H])(C(O)=O)C%10=CC(O)=CC(O)=C7%10)=O)([H])NC5=O)C=C8—
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