NPdia

BGC0000306NRPS

arylomycin

Producing organism: Streptomyces filamentosus NRRL 11379
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I)
Total steps: 9
DOI: 10.1021/ja2040877
MIBiG entry: View on MIBiG ↗

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arylomycin

C₄₆H₆₈N₆O₁₁880.49 Da

Biosynthetic (core)

Biosynthetic (additional)

Transport

Unknown

Domains

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

COM C-term

Thioesterase (TE)

Epimerization (E)

Methyltransferase

Aminotransferase I/II

TIGR01720

9 steps · 8 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions9 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`306-1`	SSIG_07966	M1	Fatty acid;Serine	`O=C(O)C(N([R])C)CO`	—
2	`306-2`	SSIG_07966	M2	306-1;Alanine from: 306-1	`O=C(NC(C)C(O)=O)C(N([R])C)CO`	—
3	`306-3`	SSIG_07967;SSIG_05823	M3	306-2;Glycine from: 306-2	`O=C(NC(C)C(NCC(O)=O)=O)C(N([R])C)CO`	—
4	`306-4`	Start	—	ρ-hydroxyphenylpyruvate	`OC1=CC=C(CC(C(O)=O)=O)C=C1`	—
5	`306-5`	SSIG_05825, SSIG_05826, SSIG_05827	—	306-4 from: 306-4	`OC1=CC=C(C(N)C(O)=O)C=C1`	—
6	`306-6`	SSIG_05823	M4	306-3;306-5 from: 306-3, 306-5	`O=C(NC(C)C(NCC(N(C)C(C1=CC=C(O)C=C1)C(O)=O)=O)=O)C(N([R])C)CO`	—
7	`306-7`	SSIG_05823	M5	306-4;Alanine from: 306-4	`O=C(NC(C)C(NCC(N(C)C(C1=CC=C(O)C=C1)C(NC(C)C(O)=O)=O)=O)=O)C(N([R])C)CO`	—
8	`306-8`	SSIG_05823, SSIG_05822	M6	306-5;Tyrosine from: 306-5	`O=C(NC(C)C(NCC(N(C)C(C1=CC=C(O)C=C1)C(NC(C)C(NC(CC2=CC=C(O)C=C2)C(O)=O)=O)=O)=O)=O)C(N([R])C)CO`	—
9	`306`	SSIG_05822	TE	306-6 from: 306-6	`O=C(NC(C)C(NCC(N(C)C(C1=CC2=C(O)C=C1)C(NC(C)C(NC(CC3=CC2=C(O)C=C3)C(O)=O)=O)=O)=O)=O)C(N([R])C)CO`	—

Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture