NPdia

BGC0000303NRPS

anthramycin

Producing organism: Streptomyces refuineus subsp. thermotolerans
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I)
Total steps: 13
DOI: 10.1016/j.chembiol.2007.05.009
MIBiG entry: View on MIBiG ↗

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anthramycin

C₁₆H₁₇N₃O₄315.12 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Transport

Unknown

Domains

Enoylreductase (ER)

Condensation (C)

Adenylation (A)

Peptidyl carrier (PCP)

Acyl carrier (ACP)

Terminal reductase

Aminotransferase V

13 steps · 11 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions13 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`303-1`	start	—	Tryptophan	`N[C@@H](C(O)=O)CC1=CNC2=CC=CC=C12`	—
2	`303-2`	ABW71848.1	—	303-1 from: 303-1	`O=C(C[C@@H](N)C(O)=O)C1=CC=CC=C1NC([H])=O`	—
3	`303-3`	?	—	303-2 from: 303-2	`CC1=CC=C(C(O)=O)C(N)=C1O`	—
4	`303-4`	start	—	Tyrosine	`N[C@H](C(O)=O)CC1=CC=C(O)C=C1`	—
5	`303-5`	?	—	303-4 from: 303-4	`N[C@H](C(O)=O)C/C(C=O)=C/C=C(O)\C(O)=O`	—
6	`303-6`	?	—	303-5 from: 303-5	`O=C(C/C=C1C=N[C@H](C(O)=O)C\1)C(O)=O`	—
7	`303-7`	?	—	303-6 from: 303-6	`C=CC1=CN[C@H](C(O)=O)C1`	—
8	`303-8`	ABW71836.1	—	303-7 from: 303-7	`CC/C=C1C=N[C@H](C(O)=O)C\1`	—
9	`303-9`	ABW71835.1	—	303-8 from: 303-8	`OC/C=C/C1=CN[C@H](C(O)=O)C1`	—
10	`303-10`	ABW71832.1,ABW71833.1,ABW71834.1	—	303-9 from: 303-9	`O=C(N)/C=C/C1=CN[C@H](C(O)=O)C1`	—
11	`303-3`	ABW71852.1	M1	303-3 from: 303-3	`CC1=CC=C(C(O)=O)C(N)=C1O`	—
12	`303-11`	ABW71853.1	M2	303-3;303-10 from: 303-3, 303-10	`OC1=C(C)C=CC(C(N2[C@H](C(O)=O)CC(/C=C/C(N)=O)=C2)=O)=C1N`	—
13	`303`	?	—	303-11 from: 303-11	`OC1=C(C)C=CC(C2=O)=C1N[C@]([C@H]3N2C=C(/C=C/C(N)=O)C3)(O)[H]`	—

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